HitPredict

Interactor 1: CBX5 (Q61686)
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: EHMT2 (Q9Z148)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein G9a)
Gene: EHMT2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25680957
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Mm			1 1263
+	Mm
		1322180 Q9DCC5_MOUSE (1-181): 4.97e-62: 192: 60.22		EHMT2_MOUSE (1-1263): 0: 985: 100.00
+	Hs
		800497 CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91		EHMT2_HUMAN (78-1263): 0: 867: 94.97
+	Hs
		1027194 CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22		EHMT2_HUMAN (78-1263): 0: 867: 94.97
+	Hs
		949863 CBX1_HUMAN (26-180): 3.2e-56: 177: 64.74		EHMT2_HUMAN (78-1263): 0: 867: 94.97
+	Hs
		800530 CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91		EHMT1_HUMAN (80-1259): 0: 656: 47.87
+	Hs
		1027268 CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22		EHMT1_HUMAN (80-1259): 0: 656: 47.87
+	Mm
		1125433 Q9DCC5_MOUSE (1-181): 4.97e-62: 192: 60.22		EHMT1_MOUSE (64-1259): 0: 645: 44.76
+	Hs
		203638 CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91		SUV91_HUMAN (914-1230): 8.33e-88: 293: 31.53
+	Hs
		203823 V9HWG0_HUMAN (1-191): 2.88e-69: 210: 97.91		SUV91_HUMAN (914-1230): 8.33e-88: 293: 31.53
+	Hs
		1331984 V9HWG0_HUMAN (1-191): 2.88e-69: 210: 97.91		SUV92_HUMAN (988-1230): 4.56e-86: 288: 36.50
+	Hs
		800527 CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91		SUV92_HUMAN (988-1230): 4.56e-86: 288: 36.50
+	Mm
		222467 CBX5_MOUSE (1-191): 1.8e-69: 211: 100.00		SUV91_MOUSE (987-1230): 7.05e-85: 285: 35.40
+	Hs
		203674 CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22		SUV91_HUMAN (914-1230): 8.33e-88: 293: 31.53
+	Hs
		1027262 CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22		SUV92_HUMAN (988-1230): 4.56e-86: 288: 36.50
+	Mm
		222468 Q9DCC5_MOUSE (1-181): 4.97e-62: 192: 60.22		SUV91_MOUSE (987-1230): 7.05e-85: 285: 35.40
+	Mm
		222460 CBX3_MOUSE (1-181): 9.27e-62: 191: 60.22		SUV91_MOUSE (987-1230): 7.05e-85: 285: 35.40
+	Mm
		613035 CBX3_MOUSE (1-181): 9.27e-62: 191: 60.22		SUV92_MOUSE (988-1230): 4.71e-83: 281: 36.88
+	Hs
		203662 CBX1_HUMAN (26-180): 3.2e-56: 177: 64.74		SUV91_HUMAN (914-1230): 8.33e-88: 293: 31.53
+	Xl
		1155581 Q802A7_XENLA (1-191): 1.96e-56: 178: 75.39		SUV91_XENLA (971-1230): 4.09e-87: 291: 35.59
+	Hs
		949887 CBX1_HUMAN (26-180): 3.2e-56: 177: 64.74		SUV92_HUMAN (988-1230): 4.56e-86: 288: 36.50