HitPredict

Interactor 1: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1
Common GO terms	GO:0005576 - extracellular region GO:0005829 - cytosol GO:0035580 - specific granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 968 Hs			1 2472
+	Mm
		82740 ANK3_MOUSE (381-967): 1e-99: 346: 14.24		B9EKJ1_MOUSE (1-2472): 0: 706: 98.18
+	Hs
		965102 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Mm
		561172 ANK2_MOUSE (63-670): 1.29e-71: 262: 12.37		SPTN1_MOUSE (1-2472): 0: 712: 98.42
+	Hs
		587530 NFKB1_HUMAN (1-968): 0: 796: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		587537 NFKB1_HUMAN (1-968): 0: 796: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		360612 ANK1_HUMAN (539-967): 7.32e-78: 281: 16.84		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Mm
		103598 ANK3_MOUSE (381-967): 1e-99: 346: 14.24		Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60
+	Hs
		164604 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Mm
		103603 ANK3_MOUSE (381-967): 1e-99: 346: 14.24		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86
+	Rn
		251022 ANK3_RAT (73-824): 5.17e-84: 299: 15.51		PLEC_RAT (1-1257): 6.84e-37: 156: 10.91
+	Hs
		556695 ANK1_HUMAN (539-967): 7.32e-78: 281: 16.84		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		963292 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		521526 TF65_HUMAN (28-420): 6.77e-116: 368: 34.41		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211566 TF65_HUMAN (28-420): 6.77e-116: 368: 34.41		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		965174 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		506803 ANK1_HUMAN (539-967): 7.32e-78: 281: 16.84		SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70
+	Hs
		883671 RIPK4_HUMAN (478-862): 1.18e-61: 227: 21.00		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		639696 IKBA_HUMAN (485-767): 1.18e-66: 228: 35.45		CENPF_HUMAN (1723-2444): 8.12e-13: 77: 9.28
+	Hs
		166740 MIB1_HUMAN (478-689): 3.14e-30: 131: 23.11		CE290_HUMAN (808-2443): 1.12e-32: 142: 10.61
+	Hs
		1206041 MIB1_HUMAN (478-689): 3.14e-30: 131: 23.11		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94