HitPredict

Interactor 1: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Interactor 2: Q9QX70 (Q9QX70)
Receptor protein-tyrosine kinase (EC 2.7.10.1)
Gene: Egfr

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15389569, 20029031, 15371442
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 810 Rn			1 1209
+	Rn
		1144032 UBC_RAT (1-810): 0: 1000: 100.00		ERBB3_RAT (3-1193): 0: 1046: 41.56
+	Hs
		337826 UBC_HUMAN (1-533): 0: 662: 99.81		EGFR_HUMAN (1-1209): 0: 1227: 90.34
+	Rn
		102578 UBC_RAT (1-810): 0: 1000: 100.00		RET_RAT (426-1083): 9.34e-133: 435: 22.67
+	Hs
		337825 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		EGFR_HUMAN (1-1209): 0: 1227: 90.34
+	Hs
		601875 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		ERBB3_HUMAN (3-1151): 0: 1051: 42.43
+	Rn
		1144325 UBC_RAT (1-810): 0: 1000: 100.00		T2CB11_RAT (346-649): 8.2e-19: 95.2: 21.19
+	Hs
		475664 UBC_HUMAN (1-533): 0: 662: 99.81		ACK1_HUMAN (692-968): 2.35e-55: 212: 39.58
+	Mm
		222822 UBC_MOUSE (1-108): 6.19e-31: 132: 90.74		ACK1_MOUSE (692-968): 1.07e-52: 203: 38.87
+	Hs
		397932 ISG15_HUMAN (228-380): 7.21e-29: 115: 32.69		ACK1_HUMAN (692-968): 2.35e-55: 212: 39.58
+	Hs
		435506 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		IGF1R_HUMAN (356-651): 5.59e-27: 121: 22.94