HitPredict

Interactor 1: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Interactor 2: MLP3A (Q91VR7)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: Map1lc3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	31286822, 18083104, 18524774, 32093570, 19765191, 23637164
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005770 - late endosome GO:0005776 - autophagosome GO:0005829 - cytosol GO:0006914 - autophagy GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0044754 - autolysosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 442 Mm			1 121
+	Mm
		1145362 SQSTM_MOUSE (1-442): 0: 777: 100.00		MLP3B_MOUSE (1-120): 3.16e-52: 162: 82.50
+	Hs
		1036900 SQSTM_HUMAN (1-442): 0: 715: 89.82		MLP3A_HUMAN (1-121): 4.19e-54: 167: 100.00
+	Hs
		891130 SQSTM_HUMAN (1-442): 0: 715: 89.82		GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74
+	Hs
		1036661 SQSTM_HUMAN (1-442): 0: 715: 89.82		Q6IAW1_HUMAN (7-121): 2.99e-52: 161: 30.44
+	Hs
		1036882 SQSTM_HUMAN (1-442): 0: 715: 89.82		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Hs
		306157 SQSTM_HUMAN (1-442): 0: 715: 89.82		GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44
+	Hs
		1036868 SQSTM_HUMAN (1-442): 0: 715: 89.82		MLP3C_HUMAN (1-120): 5.63e-51: 159: 59.17
+	Hs
		61895 SQSTM_HUMAN (1-442): 0: 715: 89.82		MP3B2_HUMAN (1-121): 4.06e-51: 159: 80.99
+	Hs
		1036891 SQSTM_HUMAN (1-442): 0: 715: 89.82		GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05
+	Ce
		94010 F1LIM5_CAEEL (79-230): 3.33e-44: 164: 23.98		LGG1_CAEEL (6-120): 1.79e-50: 157: 33.91
+	Ce
		94015 F1LIM5_CAEEL (79-230): 3.33e-44: 164: 23.98		LGG2_CAEEL (6-120): 4.95e-44: 141: 59.13
+	Hs
		306226 MIB1_HUMAN (105-228): 1.65e-27: 117: 27.69		GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44
+	Dm
		536028 REF2P_DROME (112-173): 2.24e-18: 89.4: 41.27		Q9W2S2_DROME (3-121): 3.47e-53: 164: 30.25
+	Hs
		320003 HERC2_HUMAN (120-197): 1.35e-11: 69: 32.50		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82