HitPredict

Interactor 1: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 28514442, 33961781, 34927784, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031623 - receptor internalization GO:0031901 - early endosome membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 903
+	Hs
		1155186 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		132069 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		1155176 EREP1_HUMAN (1-450): 0: 619: 100.00		NED4L_HUMAN (6-900): 0: 761: 32.31
+	Hs
		861620 EREP1_HUMAN (1-450): 0: 619: 100.00		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		1010516 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Hs
		1155156 EREP1_HUMAN (1-450): 0: 619: 100.00		HUWE1_HUMAN (415-902): 8.1e-162: 527: 34.88
+	Hs
		1010530 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		131944 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		1010517 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		NED4L_HUMAN (6-900): 0: 761: 32.31
+	Hs
		1356219 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		132181 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		861564 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		1155198 EREP1_HUMAN (1-450): 0: 619: 100.00		HECW2_HUMAN (1-498): 3.81e-15: 82.6: 10.75
+	Hs
		1010542 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		HECW2_HUMAN (1-498): 3.81e-15: 82.6: 10.75
+	Hs
		1010488 EREP3_HUMAN (3-317): 4.93e-89: 286: 26.38		HECW1_HUMAN (26-479): 3.24e-11: 69.6: 13.71