HitPredict

Interactor 1: REEP3 (Q6NUK4)
Receptor expression-enhancing protein 3
Gene: REEP3

Interactor 2: REEP2 (Q9BRK0)
Receptor expression-enhancing protein 2
Gene: REEP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005881 - cytoplasmic microtubule GO:0008017 - microtubule binding GO:0071782 - endoplasmic reticulum tubular network GO:0071786 - endoplasmic reticulum tubular network organization
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 252
+	Hs
		1310089 REEP4_HUMAN (1-250): 3.38e-91: 271: 53.70		REEP2_HUMAN (1-252): 6.8e-104: 303: 100.00
+	Hs
		1156242 REEP3_HUMAN (1-255): 5.32e-107: 311: 100.00		REEP4_HUMAN (1-245): 2.45e-85: 256: 51.74
+	Hs
		1156243 REEP3_HUMAN (1-255): 5.32e-107: 311: 100.00		REEP1_HUMAN (1-160): 4.13e-69: 213: 77.78
+	Hs
		1332291 REEP4_HUMAN (1-250): 3.38e-91: 271: 53.70		REEP1_HUMAN (1-160): 4.13e-69: 213: 77.78
+	Hs
		1310090 REEP2_HUMAN (1-250): 4.58e-86: 258: 50.39		REEP1_HUMAN (1-160): 4.13e-69: 213: 77.78
+	Hs
		961825 REEP4_HUMAN (1-250): 3.38e-91: 271: 53.70		REEP5_HUMAN (1-131): 1.49e-61: 193: 33.33
+	Hs
		961800 REEP2_HUMAN (1-250): 4.58e-86: 258: 50.39		REEP5_HUMAN (1-131): 1.49e-61: 193: 33.33
+	Hs
		961828 REEP1_HUMAN (1-162): 1.58e-72: 222: 73.46		REEP5_HUMAN (1-131): 1.49e-61: 193: 33.33
+	At
		1209447 HA22J_ARATH (1-251): 1.03e-57: 186: 24.81		HA22J_ARATH (1-211): 1.76e-68: 213: 24.23
+	Mm
		1321721 Q9CQG4_MOUSE (1-125): 2.34e-58: 185: 28.57		Q9CQG4_MOUSE (1-131): 3.02e-61: 192: 33.33
+	Hs
		961778 REEP5_HUMAN (1-125): 8.94e-59: 186: 28.57		REEP6_HUMAN (1-143): 2e-57: 183: 27.89