HitPredict

Interactor 1: PKN3 (Q6P5Z2)
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)
Gene: PKN3

Interactor 2: DEFI8 (Q6ZN54)
Differentially expressed in FDCP 8 homolog (DEF-8)
Gene: DEF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~Pkinase
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 889 Hs			1 512
+	Hs
		1081999 PKN2_HUMAN (13-884): 0: 894: 49.26		DEFI8_HUMAN (1-512): 0: 698: 100.00
+	Hs
		408621 PKN1_HUMAN (27-883): 0: 888: 51.05		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		566359 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCE_HUMAN (151-250): 8.06e-23: 104: 17.43
+	Hs
		566367 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCD_HUMAN (153-250): 5.85e-21: 98.6: 17.93
+	Hs
		408549 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		566289 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCL_HUMAN (151-250): 6.19e-21: 98.3: 15.46
+	Hs
		566272 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83
+	Hs
		408608 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		KPCD_HUMAN (153-250): 5.85e-21: 98.6: 17.93
+	Hs
		408522 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		397135 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		KPCG_HUMAN (151-250): 1.42e-18: 90.9: 15.84
+	Hs
		397122 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		KPCG_HUMAN (151-250): 1.42e-18: 90.9: 15.84
+	Mm
		554867 AKT1_MOUSE (431-883): 5.96e-159: 475: 34.28		KPCE_MOUSE (151-250): 4.12e-23: 105: 18.35
+	Hs
		681803 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		KPCD_HUMAN (153-250): 5.85e-21: 98.6: 17.93
+	Hs
		408561 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		397120 KPCG_HUMAN (401-889): 1.25e-156: 477: 33.33		KPCG_HUMAN (151-250): 1.42e-18: 90.9: 15.84
+	Hs
		408644 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		GRP3_HUMAN (201-250): 3.15e-09: 61.6: 28.00
+	Hs
		681799 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		KPCT_HUMAN (201-250): 1.39e-14: 78.6: 24.00