HitPredict

Interactor 1: UBP49 (Q70CQ1)
Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)
Gene: USP49

Interactor 2: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30943264, 27801882
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 379
+	Mm
		1111213 UBP33_MOUSE (4-678): 2.68e-107: 348: 17.03		STING_MOUSE (1-378): 0: 588: 69.05
+	Mm
		1111067 UBP20_MOUSE (2-678): 1.03e-99: 328: 16.96		STING_MOUSE (1-378): 0: 588: 69.05
+	Hs
		271135 UBP2_HUMAN (55-659): 4e-109: 344: 19.50		STING_HUMAN (1-379): 0: 572: 100.00
+	Hs
		1203594 UBP20_HUMAN (2-678): 2.8e-97: 321: 17.75		STING_HUMAN (1-379): 0: 572: 100.00
+	Hs
		1203593 UBP22_HUMAN (283-662): 9.54e-98: 312: 24.01		STING_HUMAN (1-379): 0: 572: 100.00
+	Hs
		1203599 UBP3_HUMAN (4-160): 5.8e-25: 111: 23.08		STING_HUMAN (1-379): 0: 572: 100.00