Interactor 1: RSPO1 (Q2MKA7)
R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)
Gene: RSPO1
Interactor 2: ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
Gene: ZNRF3
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.87 | 1.00 | 0.937 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24050775, 24165923, 25504990, 29752411, 22575959 |
| Identification Methods | fluorescent resonance energy transfer, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, surface plasmon resonance |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Furin-like_2~ZNRF_3_ecto |
| Common GO terms | GO:0016055 - Wnt signaling pathway |
| Homologous interactions | 9 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
