Protein: ZNRF3
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)

Gene: ZNRF3
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q9ULT6

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005109 - frizzled binding
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1250145

RSPO2
R-spondin-2

6

9

Small-scale

0.937

High

1179082

RSPO1
R-spondin-1

5

9

Small-scale

0.937

High

1416702

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

5

3

Small-scale

0.915

High

1417593

RSPO3
R-spondin-3

3

9

Small-scale

0.845

High

1461682

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

2

16

Small-scale

0.768

High

282971

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

2

4

Small-scale

0.737

High

957865

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

1229131

RNF43
E3 ubiquitin-protein ligase RNF43

1

16

Small-scale

0.647

High

1203833

TTMP
TPA-induced transmembrane protein

2

1

High-throughput

0.606

High

159916

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

7

Small-scale

0.584

High

287630

LRP6
Low-density lipoprotein receptor-related protein 6

2

0

Small-scale

0.576

High

922849

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

5

High-throughput

0.536

High

1275321

PLPR4
Phospholipid phosphatase-related protein type 4

1

1

High-throughput

0.536

High

1349906

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.536

High

1391392

MRAP2
Melanocortin-2 receptor accessory protein 2

1

1

High-throughput

0.536

High

1461685

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

619231

EPOR
Erythropoietin receptor

1

10

Small-scale

0.501

High

415929

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.494

High

1316013

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1217777

GFI1B
Zinc finger protein Gfi-1b

1

0

High-throughput

0.486

High

159408

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

8

Small-scale

0.479

High

247542

FZD6
Frizzled-6

1

6

Small-scale

0.479

High

270490

FZD7
Frizzled-7

1

6

Small-scale

0.479

High

472145

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.479

High

639847

TAF1
Transcription initiation factor TFIID subunit 1

1

2

High-throughput

0.479

High

1112789

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1249320

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1461683

FZD4
Frizzled-4

1

6

Small-scale

0.479

High

1461684

FBW1A
F-box/WD repeat-containing protein 1A

1

8

Small-scale

0.479

High

992392

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

876448

EAA4
Excitatory amino acid transporter 4

1

2

High-throughput

0.445

High

1063087

S20A2
Sodium-dependent phosphate transporter 2

1

2

High-throughput

0.445

High

1133818

SL9A5
Sodium/hydrogen exchanger 5

1

7

High-throughput

0.445

High

1310979

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

10

High-throughput

0.445

High

1346831

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

10

High-throughput

0.445

High

1437142

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

2

Small-scale

0.437

High

885448

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025