HitPredict

Interactor 1: RSPO2 (Q6UXX9)
R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
Gene: RSPO2

Interactor 2: ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
Gene: ZNRF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	25504990, 29752411, 29769720, 24050775, 28600110, 37402772
Identification Methods	pull down, affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like_2~ZNRF_3_ecto
Common GO terms	GO:0060173 - limb development
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 936
+	Mm
		1210581 RSPO2_MOUSE (1-243): 1.96e-78: 238: 95.89		ZNRF3_MOUSE (56-921): 0: 731: 85.81
+	Hs
		1179082 RSPO1_HUMAN (1-231): 1.31e-63: 200: 41.45		ZNRF3_HUMAN (1-936): 0: 730: 100.00
+	Hs
		1417593 RSPO3_HUMAN (1-204): 4.86e-55: 179: 48.56		ZNRF3_HUMAN (1-936): 0: 730: 100.00
+	Xl
		1195177 RSPO2_XENLA (1-243): 4.52e-76: 232: 83.95		ZNRF3_XENLA (100-916): 4.02e-163: 498: 54.75
+	Hs
		1228971 RSPO2_HUMAN (1-243): 1.08e-79: 241: 100.00		RNF43_HUMAN (42-781): 1.01e-102: 339: 29.13
+	Hs
		1179073 RSPO1_HUMAN (1-231): 1.31e-63: 200: 41.45		RNF43_HUMAN (42-781): 1.01e-102: 339: 29.13
+	Hs
		465578 IGF1R_HUMAN (14-160): 3.63e-34: 131: 24.05		RN149_HUMAN (46-369): 4.5e-79: 264: 19.16
+	Hs
		465407 IGF1R_HUMAN (14-160): 3.63e-34: 131: 24.05		CBL_HUMAN (293-796): 5.03e-56: 211: 11.80
+	Hs
		465563 IGF1R_HUMAN (14-160): 3.63e-34: 131: 24.05		SYVN1_HUMAN (39-637): 9.91e-53: 197: 15.02