Protein: RSPO2
R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)

Gene: RSPO2
Organism: Homo sapiens
Interactions: 23
UniProt ID: Q6UXX9

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008201 - heparin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1250145

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

6

9

Small-scale

0.937

High

1250143

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

4

8

Small-scale

0.885

High

282966

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

2

7

Small-scale

0.806

High

1228971

RNF43
E3 ubiquitin-protein ligase RNF43

2

8

Small-scale

0.721

High

950301

KR107
Keratin-associated protein 10-7

3

12

High-throughput

0.616

High

70295

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

885304

HXA1
Homeobox protein Hox-A1

2

7

High-throughput

0.553

High

949575

KR123
Keratin-associated protein 12-3

2

1

High-throughput

0.553

High

950179

KR106
Keratin-associated protein 10-6

2

13

High-throughput

0.553

High

1250140

CTSR1
Cation channel sperm-associated protein 1

2

2

High-throughput

0.553

High

1250141

S39A7
Zinc transporter SLC39A7

2

1

High-throughput

0.553

High

1250142

ZN837
Zinc finger protein 837

2

2

High-throughput

0.553

High

1250146

ZN330
Zinc finger protein 330

2

1

High-throughput

0.553

High

950809

KR109
Keratin-associated protein 10-9

1

13

High-throughput

0.523

High

1250144

PKHF2
Pleckstrin homology domain-containing family F member 2

1

7

High-throughput

0.523

High

656160

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.470

High

950219

KR104
Keratin-associated protein 10-4

1

12

High-throughput

0.470

High

1250139

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.470

High

270461

FZD7
Frizzled-7

1

0

Small-scale

0.458

High

872452

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

949729

KR101
Keratin-associated protein 10-1

1

13

High-throughput

0.439

High

216469

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.265

Low

1239610

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025