Protein: RSPO1
R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)

Gene: RSPO1
Organism: Homo sapiens
Interactions: 26
UniProt ID: Q2MKA7

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0002090 - regulation of receptor internalization
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1179082

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

5

9

Small-scale

0.937

High

1179078

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

5

9

Small-scale

0.917

High

1179073

RNF43
E3 ubiquitin-protein ligase RNF43

2

8

Small-scale

0.768

High

282965

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

1

8

Small-scale

0.747

High

1058045

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

0

High-throughput

0.638

High

1179079

LACRT
Extracellular glycoprotein lacritin

3

0

High-throughput

0.638

High

1179074

ZN579
Zinc finger protein 579

2

1

High-throughput

0.611

High

1179072

HECD3
E3 ubiquitin-protein ligase HECTD3

3

3

High-throughput

0.609

High

207818

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

2

1

High-throughput

0.558

High

595448

H15
Histone H1.5

1

1

High-throughput

0.515

High

1179071

H2B2F
Histone H2B type 2-F

1

1

High-throughput

0.515

High

1179076

SORL
Sortilin-related receptor

1

6

High-throughput

0.479

High

773746

ACTN2
Alpha-actinin-2

1

3

High-throughput

0.445

High

996465

ACTS
Actin, alpha skeletal muscle

1

2

High-throughput

0.445

High

1179080

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

5

High-throughput

0.437

High

67552

MYH7B
Myosin-7B

1

5

High-throughput

0.407

High

535940

MYH3
Myosin-3

1

5

High-throughput

0.407

High

556855

MYH1
Myosin-1

1

5

High-throughput

0.407

High

563016

MYH6
Myosin-6

1

5

High-throughput

0.407

High

1179077

MYL11
Myosin regulatory light chain 11

1

1

High-throughput

0.407

High

1179081

MYH2
Myosin-2

1

5

High-throughput

0.407

High

1179084

MYH4
Myosin-4

1

5

High-throughput

0.407

High

1179075

CEP76
Centrosomal protein of 76 kDa

3

0

High-throughput

0.347

High

1179083

CHTOP
Chromatin target of PRMT1 protein

3

0

High-throughput

0.347

High

642233

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.268

Low

437586

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025