HitPredict

Interactor 1: EYA2 (O00167)
Eyes absent homolog 2 (EC 3.1.3.48)
Gene: EYA2

Interactor 2: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27880917
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 5537
+	Hs
		123781 SPT5H_HUMAN (5-305): 2.65e-35: 143: 15.22		KMT2D_HUMAN (1-5537): 0: 1986: 100.00
+	Hs
		152667 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		KMT2D_HUMAN (1-5537): 0: 1986: 100.00
+	Hs
		1080268 EYA1_HUMAN (3-538): 0: 523: 62.50		EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91
+	Hs
		123953 SPT5H_HUMAN (5-305): 2.65e-35: 143: 15.22		EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91
+	Hs
		967206 EWS_HUMAN (19-268): 1.95e-20: 96.9: 16.91		EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91
+	Hs
		967436 EWS_HUMAN (19-268): 1.95e-20: 96.9: 16.91		SUV92_HUMAN (5155-5537): 2.78e-91: 306: 18.07
+	Hs
		1080127 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91
+	Hs
		123917 SPT5H_HUMAN (5-305): 2.65e-35: 143: 15.22		KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24
+	Hs
		967541 EWS_HUMAN (19-268): 1.95e-20: 96.9: 16.91		PCLO_HUMAN (772-4721): 1.4e-32: 143: 7.94
+	Hs
		967120 EWS_HUMAN (19-268): 1.95e-20: 96.9: 16.91		KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24
+	Hs
		975285 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24
+	Hs
		1243852 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31
+	Dm
		52421 A1Z7J7_DROME (20-261): 1.58e-21: 101: 14.52		X2JDJ3_DROME (668-1245): 4.35e-11: 72.2: 14.46
+	Mm
		1351630 PCLO_MOUSE (76-268): 1.08e-09: 63.8: 7.73		PCLO_MOUSE (3974-4802): 1.38e-21: 107: 11.89
+	Hs
		165699 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15
+	Hs
		1243853 KMT2C_HUMAN (1-272): 3.09e-09: 62.2: 9.62		SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89
+	Dm
		113976 M9PB30_DROME (78-260): 3.05e-10: 65.3: 12.31		M9PB30_DROME (4122-4751): 2.37e-12: 76.7: 14.20