HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12711675
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Chromo~DNA_methylase, Chromo_shadow~DNA_methylase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 185
+	Hs
		684988 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		CBX3_HUMAN (1-177): 2.12e-63: 195: 69.49
+	Hs
		684945 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		CBX5_HUMAN (1-183): 9.64e-60: 186: 57.45
+	Hs
		216379 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		SUV91_HUMAN (13-121): 4.24e-29: 112: 21.10
+	Hs
		338774 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		CBX6_HUMAN (12-101): 1.26e-25: 103: 30.00
+	Hs
		1097604 DNM3B_HUMAN (1130-1325): 7e-42: 169: 17.65		CBX3_HUMAN (1-177): 2.12e-63: 195: 69.49
+	Hs
		1014221 DNM3B_HUMAN (1130-1325): 7e-42: 169: 17.65		CBX1_HUMAN (1-185): 2.22e-62: 193: 100.00
+	Hs
		853425 DNM3B_HUMAN (1130-1325): 7e-42: 169: 17.65		CBX5_HUMAN (1-183): 9.64e-60: 186: 57.45
+	Hs
		1014242 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		CBX1_HUMAN (1-185): 2.22e-62: 193: 100.00
+	Dm
		426782 Q9VKB3_DROME (1139-1371): 1.51e-48: 179: 19.09		HP1_DROME (1-176): 7.92e-50: 161: 42.23
+	Hs
		853445 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		CBX5_HUMAN (1-183): 9.64e-60: 186: 57.45
+	Hs
		216552 DNM3B_HUMAN (1130-1325): 7e-42: 169: 17.65		SUV91_HUMAN (13-121): 4.24e-29: 112: 21.10
+	Hs
		1097353 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX3_HUMAN (1-177): 2.12e-63: 195: 69.49
+	Hs
		1014130 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX1_HUMAN (1-185): 2.22e-62: 193: 100.00
+	Mm
		312439 DNM3B_MOUSE (1124-1325): 7.74e-40: 163: 18.52		CBX2_MOUSE (10-110): 1.42e-25: 104: 29.70
+	Hs
		216573 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		SUV91_HUMAN (13-121): 4.24e-29: 112: 21.10
+	Hs
		853302 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX5_HUMAN (1-183): 9.64e-60: 186: 57.45
+	Hs
		1097514 MINT_HUMAN (9-691): 1.07e-09: 66: 7.99		CBX3_HUMAN (1-177): 2.12e-63: 195: 69.49
+	Hs
		129835 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		CBX4_HUMAN (12-89): 1.01e-24: 101: 34.62
+	At
		1375185 CMT3_ARATH (877-1204): 2.77e-13: 77.1: 17.34		LHP1_ARATH (17-109): 1.08e-14: 72.9: 34.04