HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.946

Property	Details
Experiments	8662772, 8610109, 9507002, 9685397, 22973453, 16273093
Identification Methods	pull down, affinity chromatography technology, unspecified method, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 594
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (3-593): 1.24e-176: 514: 47.55
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (108-593): 5.71e-152: 447: 51.91
+	Hs
		338278 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC2_HUMAN (47-593): 4.99e-147: 438: 43.96
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (361-594): 1.83e-49: 181: 17.46
+	Hs
		275521 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (302-594): 1.16e-49: 184: 20.07
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (361-594): 1.75e-48: 179: 17.39
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (424-594): 2.65e-47: 179: 25.43
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (359-594): 1.87e-47: 175: 18.22
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (445-594): 3.77e-35: 133: 22.08
+	Hs
		337779 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FES_HUMAN (431-594): 4.92e-36: 146: 22.56
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (445-594): 1.28e-34: 132: 22.08
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56