HitPredict

Interactor 1: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.80	0.731

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 538
+	Hs
		1189463 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		NECT3_HUMAN (30-389): 3.83e-72: 241: 25.00
+	Hs
		545132 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72
+	Hs
		484677 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		1189476 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		NTRI_HUMAN (20-360): 4.8e-54: 187: 15.58
+	Hs
		484720 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		NECT3_HUMAN (30-389): 3.83e-72: 241: 25.00
+	Hs
		1031145 NT2NA_HUMAN (1-236): 1e-44: 151: 100.00		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		484560 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72
+	Ce
		103935 SLIT1_CAEEL (86-233): 3.34e-21: 93.9: 27.74		SAX3_CAEEL (33-444): 1.01e-47: 180: 13.54
+	Hs
		484728 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		NTRI_HUMAN (20-360): 4.8e-54: 187: 15.58
+	Hs
		980481 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		PXDN_HUMAN (245-533): 1.24e-44: 171: 12.33
+	Dm
		621596 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9VQ08_DROME (348-538): 5.69e-20: 96.3: 10.26
+	Dm
		621592 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9GPP7_DROME (348-538): 7.31e-20: 95.9: 10.26
+	Dm
		422809 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		Q9BN17_DROME (23-361): 4.49e-34: 139: 15.95
+	Hs
		484602 NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Dm
		219803 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		O44924_DROME (347-538): 1.1e-16: 85.9: 9.27
+	Dm
		621597 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9W213_DROME (347-538): 1.05e-16: 85.9: 9.27
+	Dm
		621591 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9GPP6_DROME (24-365): 1.04e-15: 82.9: 9.24
+	Dm
		621595 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q9VPZ7_DROME (24-365): 9.53e-16: 82.9: 9.24
+	Dm
		621590 SLIT_DROME (68-233): 1.89e-31: 123: 33.53		Q5U176_DROME (382-538): 4.47e-13: 74.4: 10.06
+	Mm
		292557 SLIT3_MOUSE (71-188): 8.65e-12: 66.2: 27.05		ROBO1_MOUSE (348-538): 4.54e-18: 90.2: 8.59