HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 26416283, 12842890
Identification Methods enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Cbl_N~Cbl_N, Cbl_N~Cbl_N2, Cbl_N~Cbl_N3, Cbl_N~zf-C3HC4, Cbl_N2~Cbl_N2, Cbl_N2~Cbl_N3, Cbl_N2~zf-C3HC4, Cbl_N3~zf-C3HC4, zf-C3HC4~zf-C3HC4
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0004842 - ubiquitin-protein transferase activity
GO:0005509 - calcium ion binding
and 21 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 982
Mm

1 982
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm

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Last updated: 11Aug2025