HitPredict

Interactor 1: RB6I2 (Q8IUD2)
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
Gene: ERC1

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	20932476, 15218148
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008385 - IkappaB kinase complex GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1116 Hs			1 419
+	Mm
		291816 RB6I2_MOUSE (1-1116): 7.32e-82: 292: 96.88		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		725092 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		724957 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		528386 MYH6_HUMAN (3-544): 6.64e-24: 111: 9.47		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		725086 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		725065 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		725097 MYH11_HUMAN (2-719): 7.51e-34: 144: 10.30		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		724686 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		724687 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		522657 MYH4_HUMAN (418-1116): 7.23e-33: 141: 13.92		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528435 MYH4_HUMAN (418-1116): 7.23e-33: 141: 13.92		MYH8_HUMAN (22-392): 1.71e-09: 62.3: 11.87
+	Hs
		724943 MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		528432 MYH13_HUMAN (1-745): 5.53e-31: 134: 9.88		MYH8_HUMAN (22-392): 1.71e-09: 62.3: 11.87
+	Hs
		166821 ERC2_HUMAN (283-1051): 5.93e-28: 124: 13.05		LIPA2_HUMAN (31-337): 5.02e-10: 63.9: 15.53
+	Rn
		361106 MYH6_RAT (3-698): 6.68e-29: 127: 10.00		MYH6_RAT (4-395): 9.94e-09: 59.6: 10.53
+	Dm
		1303379 MYSN_DROME (523-1115): 2.29e-26: 119: 12.29		MYSN_DROME (48-367): 2.18e-10: 65: 19.89
+	Hs
		528356 MYH6_HUMAN (3-544): 6.64e-24: 111: 9.47		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		522585 MYH7_HUMAN (6-513): 7.72e-21: 101: 9.84		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24