HitPredict

Interactor 1: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Interactor 2: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	32117091, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 296
+	Hs
		199139 SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Mm
		607562 RNF41_MOUSE (25-152): 1.48e-32: 123: 17.65		MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76
+	Hs
		1024747 TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Hs
		120151 TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79		TLR4_HUMAN (153-293): 2.58e-46: 168: 26.00
+	Hs
		1290202 RN125_HUMAN (9-198): 3.5e-31: 117: 18.27		ILRL2_HUMAN (145-293): 1.11e-38: 144: 16.96
+	Hs
		1024765 TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79		IL1AP_HUMAN (145-295): 1.04e-41: 153: 25.47
+	Hs
		179933 TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79		TLR3_HUMAN (160-293): 1.03e-35: 137: 18.75