HitPredict

Interactor 1: MEN1 (O00255)
Menin
Gene: MEN1

Interactor 2: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	23508102, 35850772, 18598942
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LEDGF~Menin
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 610 Hs			1 530
+	Hs
		122981 MEN1_HUMAN (1-610): 0: 1181: 100.00		NSD3_HUMAN (4-445): 6.35e-74: 257: 14.91
+	Hs
		122802 MEN1_HUMAN (1-610): 0: 1181: 100.00		GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27
+	Hs
		123087 MEN1_HUMAN (1-610): 0: 1181: 100.00		ZMYD8_HUMAN (10-490): 5.97e-17: 86.4: 13.32
+	Hs
		122891 MEN1_HUMAN (1-610): 0: 1181: 100.00		THOC2_HUMAN (106-366): 2.25e-09: 62.4: 14.59