HitPredict

Interactor 1: MCLN2 (Q8IZK6)
Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2)
Gene: MCOLN2

Interactor 2: MCLN3 (Q8TDD5)
Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)
Gene: MCOLN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PKD_channel~PKD_channel
Common GO terms	GO:0005262 - calcium channel activity GO:0005886 - plasma membrane GO:0031902 - late endosome membrane GO:0070588 - calcium ion transmembrane transport GO:0072345 - NAADP-sensitive calcium-release channel activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 566 Hs			1 553
+	Hs
		1224493 MCLN2_HUMAN (1-566): 0: 851: 100.00		MCLN1_HUMAN (37-553): 0: 766: 56.96
+	Hs
		1254993 MCLN3_HUMAN (38-555): 0: 783: 59.50		MCLN1_HUMAN (37-553): 0: 766: 56.96
+	Mm
		1307603 MCLN1_MOUSE (36-561): 0: 766: 47.90		MCLN1_MOUSE (26-553): 0: 766: 57.06
+	Hs
		1326669 MCLN1_HUMAN (40-561): 0: 765: 48.33		MCLN1_HUMAN (37-553): 0: 766: 56.96