HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: PFKAP (Q01813)
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene: PFKP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 784
+	Hs
		601497 FGFR2_HUMAN (1-821): 0: 803: 71.21		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		607944 FGFR4_HUMAN (29-808): 0: 664: 55.60		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		665468 EPHA8_HUMAN (3-819): 0: 603: 19.35		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		966706 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		384669 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		437757 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		437718 UFO_HUMAN (8-815): 1.07e-155: 479: 21.98		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		384121 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		437721 FLT3_HUMAN (462-754): 8.76e-79: 276: 43.47		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		572623 VGFR1_HUMAN (48-362): 8.54e-23: 107: 18.73		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		729265 VGFR3_HUMAN (31-128): 2.94e-10: 66.3: 21.15		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Mm
		519479 PTK7_MOUSE (162-433): 2.54e-17: 89: 16.36		PFKAL_MOUSE (19-779): 0: 1023: 69.42
+	Hs
		571668 FGFR3_HUMAN (6-821): 0: 730: 61.22		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571675 EPHA8_HUMAN (3-819): 0: 603: 19.35		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571677 UFO_HUMAN (8-815): 1.07e-155: 479: 21.98		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		384225 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571682 FLT3_HUMAN (462-754): 8.76e-79: 276: 43.47		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571707 TIE2_HUMAN (484-771): 3.85e-69: 250: 45.52		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571663 VGFR1_HUMAN (48-362): 8.54e-23: 107: 18.73		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571681 VGFR3_HUMAN (31-128): 2.94e-10: 66.3: 21.15		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03