HitPredict

Interactor 1: CRK (Q63768)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: PAXI (Q66H76)
Paxillin
Gene: Pxn

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11146548, 9348226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape GO:0016477 - cell migration GO:1901652 - response to peptide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Rn			1 586
+	Rn
		1216893 CRKL_RAT (2-303): 2.52e-61: 198: 47.59		PAXI_RAT (12-586): 3.58e-140: 420: 100.00
+	Hs
		855556 CRK_HUMAN (1-304): 3.64e-71: 224: 99.67		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Mm
		1225137 CRK_MOUSE (1-304): 2.05e-71: 224: 99.34		PAXI_MOUSE (12-586): 7.85e-126: 384: 86.04
+	Gg
		878593 CRK_CHICK (1-304): 4.34e-67: 213: 83.61		PAXI_CHICK (1-586): 5.89e-125: 380: 83.31
+	Hs
		855835 CRKL_HUMAN (2-303): 8.22e-62: 199: 47.27		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Mm
		868843 CRKL_MOUSE (2-303): 2.24e-61: 198: 47.27		PAXI_MOUSE (12-586): 7.85e-126: 384: 86.04
+	Hs
		878427 GRB2_HUMAN (140-295): 1.45e-26: 105: 17.14		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Hs
		878487 DNMBP_HUMAN (137-304): 9.2e-21: 94.8: 18.94		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Hs
		222034 NCK2_HUMAN (2-86): 3.69e-13: 70.9: 19.77		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Hs
		593944 NCK1_HUMAN (16-222): 5.73e-10: 61.7: 14.69		PAXI_HUMAN (12-586): 6.26e-128: 389: 81.61
+	Hs
		855785 CRK_HUMAN (1-304): 3.64e-71: 224: 99.67		ZKSC7_HUMAN (154-409): 3.67e-24: 109: 10.32
+	Hs
		159142 VAV_HUMAN (11-189): 5.07e-47: 170: 28.21		ABLM1_HUMAN (390-585): 1.47e-41: 162: 26.21
+	Hs
		159249 Q96D37_HUMAN (11-189): 3.96e-47: 170: 28.21		ABLM1_HUMAN (390-585): 1.47e-41: 162: 26.21
+	Hs
		222031 NCK2_HUMAN (2-86): 3.69e-13: 70.9: 19.77		LIMS1_HUMAN (350-585): 6.01e-63: 212: 30.86
+	Hs
		159183 GRB2_HUMAN (140-295): 1.45e-26: 105: 17.14		ABLM1_HUMAN (390-585): 1.47e-41: 162: 26.21
+	Hs
		322497 GRB2_HUMAN (140-295): 1.45e-26: 105: 17.14		ABLM3_HUMAN (411-585): 3.69e-41: 160: 29.57
+	Hs
		987967 GRB2_HUMAN (140-295): 1.45e-26: 105: 17.14		PDLI7_HUMAN (468-585): 3.42e-33: 134: 33.90
+	Hs
		599311 PLCG2_HUMAN (1-301): 8.92e-27: 112: 16.20		ZKSC7_HUMAN (154-409): 3.67e-24: 109: 10.32
+	Mm
		266989 PLCG2_MOUSE (11-301): 2.09e-26: 111: 16.83		FHL2_MOUSE (323-462): 6.78e-24: 103: 26.39
+	Hs
		222090 NCK2_HUMAN (2-86): 3.69e-13: 70.9: 19.77		TRIP6_HUMAN (467-585): 3.93e-23: 104: 28.69