HitPredict

Interactor 1: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Interactor 2: KEAP1 (Q9Z2X8)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2)
Gene: KEAP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	28820283, 31362587, 20173742
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 442 Mm			1 624
+	Hs
		1107704 SQSTM_HUMAN (1-442): 0: 715: 89.82		KEAP1_HUMAN (1-624): 0: 597: 94.07
+	Hs
		1108237 SQSTM_HUMAN (1-442): 0: 715: 89.82		KLHL9_HUMAN (36-610): 5.62e-162: 479: 27.67
+	Hs
		1108236 SQSTM_HUMAN (1-442): 0: 715: 89.82		KLHL8_HUMAN (517-624): 4.08e-22: 102: 28.44
+	Hs
		1108257 SQSTM_HUMAN (1-442): 0: 715: 89.82		KLHL3_HUMAN (513-623): 4.12e-21: 99.5: 27.03
+	Hs
		161294 SQSTM_HUMAN (1-442): 0: 715: 89.82		ENC1_HUMAN (519-620): 2.23e-13: 75.2: 19.42
+	Dm
		571063 REF2P_DROME (112-173): 2.25e-18: 89.4: 41.27		Q7KSF5_DROME (1-612): 2.82e-167: 498: 44.90