Protein: KLHL8
Kelch-like protein 8

Gene: KLHL8
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9P2G9

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114518

CUL3
Cullin-3

10

20

Small-scale

0.973

High

188604

SIGL5
Sialic acid-binding Ig-like lectin 5

2

5

High-throughput

0.726

High

1094431

CSN1
COP9 signalosome complex subunit 1

1

15

High-throughput

0.691

High

1328684

KCD17
BTB/POZ domain-containing protein KCTD17

1

4

High-throughput

0.691

High

473151

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

2

High-throughput

0.662

High

1371751

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.656

High

974069

RUXF
Small nuclear ribonucleoprotein F

3

0

High-throughput

0.646

High

1272580

CSN6
COP9 signalosome complex subunit 6

2

11

High-throughput

0.628

High

1368907

RBP56
TATA-binding protein-associated factor 2N

2

6

High-throughput

0.628

High

1407608

TCPH
T-complex protein 1 subunit eta

2

3

High-throughput

0.628

High

1429208

UBA5
Ubiquitin-like modifier-activating enzyme 5

2

1

High-throughput

0.628

High

1430085

RGAP1
Rac GTPase-activating protein 1

2

2

High-throughput

0.628

High

1200339

ANR39
Ankyrin repeat domain-containing protein 39

1

2

High-throughput

0.618

High

1454592

KLHL8
Kelch-like protein 8

1

20

High-throughput

0.618

High

764240

CAH8
Carbonic anhydrase-related protein

2

1

High-throughput

0.606

High

853859

MK09
Mitogen-activated protein kinase 9

2

3

High-throughput

0.606

High

480334

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.602

High

1451586

GEMI8
Gem-associated protein 8

2

0

High-throughput

0.602

High

868784

LEG7
Galectin-7

2

0

High-throughput

0.585

High

126262

ST2B1
Sulfotransferase 2B1

2

0

High-throughput

0.580

High

552900

RLBP1
Retinaldehyde-binding protein 1

2

0

High-throughput

0.580

High

1277081

ARMC9
LisH domain-containing protein ARMC9

2

0

High-throughput

0.580

High

1334085

P5I13
Tumor protein p53-inducible protein 13

2

0

High-throughput

0.580

High

882202

TCPG
T-complex protein 1 subunit gamma

2

3

High-throughput

0.574

High

1393005

CC120
Coiled-coil domain-containing protein 120

2

2

High-throughput

0.574

High

536201

PNMT
Phenylethanolamine N-methyltransferase

2

2

High-throughput

0.553

High

259154

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.536

High

471940

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.536

High

478239

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

485752

RU2A
U2 small nuclear ribonucleoprotein A'

1

5

High-throughput

0.536

High

958726

CSN2
COP9 signalosome complex subunit 2

1

19

High-throughput

0.536

High

974209

RUXG
Small nuclear ribonucleoprotein G

1

4

High-throughput

0.536

High

983999

RBX1
E3 ubiquitin-protein ligase RBX1

1

7

High-throughput

0.536

High

1307531

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

1370425

CSN5
COP9 signalosome complex subunit 5

1

13

High-throughput

0.536

High

1391965

DCNL1
DCN1-like protein 1

1

10

High-throughput

0.536

High

1404990

GA2L1
GAS2-like protein 1

1

2

High-throughput

0.536

High

1406133

CSN8
COP9 signalosome complex subunit 8

1

3

High-throughput

0.536

High

1416798

5NT1A
Cytosolic 5'-nucleotidase 1A

1

1

High-throughput

0.536

High

1420090

GSX2
GS homeobox 2

1

1

High-throughput

0.536

High

1447725

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.536

High

1452415

SPHK1
Sphingosine kinase 1

1

1

High-throughput

0.536

High

1454595

CSN3
COP9 signalosome complex subunit 3

1

17

High-throughput

0.536

High

1454596

NEUR2
Sialidase-2

1

2

High-throughput

0.536

High

378788

LV657
Immunoglobulin lambda variable 6-57

1

3

High-throughput

0.514

High

1431929

PDCL3
Phosducin-like protein 3

1

0

High-throughput

0.513

High

1454594

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.513

High

1116808

RAPSN
43 kDa receptor-associated protein of the synapse

1

3

Small-scale

0.512

High

927587

ATX1
Ataxin-1

1

4

High-throughput

0.508

High

1454593

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.493

High

155881

DPYL4
Dihydropyrimidinase-related protein 4

1

1

High-throughput

0.489

High

569277

YJU2B
Probable splicing factor YJU2B

1

2

High-throughput

0.489

High

666033

IBP5
Insulin-like growth factor-binding protein 5

1

3

High-throughput

0.489

High

668795

CO8A2
Collagen alpha-2(VIII) chain

1

7

High-throughput

0.489

High

876208

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.489

High

1007319

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.489

High

1187786

SP6
Transcription factor Sp6

1

4

High-throughput

0.489

High

1260661

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

1

High-throughput

0.489

High

1322364

ZN444
Zinc finger protein 444

1

5

High-throughput

0.489

High

1392389

XAGE2
X antigen family member 2

1

1

High-throughput

0.489

High

1416779

RFIP5
Rab11 family-interacting protein 5

1

1

High-throughput

0.489

High

800141

COIL
Coilin

1

0

High-throughput

0.486

High

765957

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

1108236

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1161421

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.479

High

610926

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.470

High

1234661

Q6IPC0
Protein phosphatase 1F

1

1

High-throughput

0.470

High

786902

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

884854

PPM1F
Protein phosphatase 1F

1

1

High-throughput

0.439

High

516052

CSH2
Chorionic somatomammotropin hormone 2

1

1

High-throughput

0.437

High

973836

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.426

High

516033

CSH1
Chorionic somatomammotropin hormone 1

1

1

High-throughput

0.407

High

787839

PEDF
Pigment epithelium-derived factor

2

0

High-throughput

0.328

High

1417690

TX101
Testis-expressed protein 101

2

0

High-throughput

0.316

High

221299

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.279

Low

282542

PAGE1
P antigen family member 1

1

0

High-throughput

0.279

Low

1204704

TCAL5
Transcription elongation factor A protein-like 5

1

0

High-throughput

0.279

Low

1292678

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

1370914

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1397754

MAGBA
Melanoma-associated antigen B10

1

0

High-throughput

0.279

Low

1438687

WFDC1
WAP four-disulfide core domain protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025