Protein: IRF1
Interferon regulatory factor 1 (IRF-1)

Gene: IRF1
Organism: Homo sapiens
Interactions: 156
UniProt ID: P10914

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501037

IRF8
Interferon regulatory factor 8

5

16

Small-scale

0.920

High

500981

IRF2
Interferon regulatory factor 2

4

16

Small-scale

0.878

High

501032

IRF9
Interferon regulatory factor 9

3

15

Small-scale

0.849

High

501078

IRF7
Interferon regulatory factor 7

3

15

Small-scale

0.839

High

501010

STAT1
Signal transducer and activator of transcription 1-alpha/beta

24

20

Small-scale

0.766

High

501004

C2TA
MHC class II transactivator

11

7

Small-scale

0.751

High

501095

CHIP
E3 ubiquitin-protein ligase CHIP

7

5

Small-scale

0.749

High

501043

EP300
Histone acetyltransferase p300

6

18

Small-scale

0.726

High

501041

TF65
Transcription factor p65

5

20

Small-scale

0.702

High

501033

MDM2
E3 ubiquitin-protein ligase Mdm2

4

2

Small-scale

0.694

High

352861

IFNB
Interferon beta

4

20

Small-scale

0.676

High

364096

CXL10
C-X-C motif chemokine 10

4

10

Small-scale

0.676

High

500991

NFKB1
Nuclear factor NF-kappa-B p105 subunit

4

20

Small-scale

0.676

High

501008

STAT3
Signal transducer and activator of transcription 3

4

20

Small-scale

0.676

High

500987

SPI1
Transcription factor PU.1

2

10

Small-scale

0.646

High

501050

IRF3
Interferon regulatory factor 3

1

16

Small-scale

0.646

High

501039

TAP1
Antigen peptide transporter 1

5

3

Small-scale

0.641

High

501045

TIF1B
Transcription intermediary factor 1-beta

2

15

Small-scale

0.639

High

214054

SPOP
Speckle-type POZ protein

2

2

Small-scale

0.625

High

501046

BIRC3
Baculoviral IAP repeat-containing protein 3

2

3

Small-scale

0.624

High

501047

IRF5
Interferon regulatory factor 5

1

15

Small-scale

0.618

High

501001

IL12A
Interleukin-12 subunit alpha

4

7

Small-scale

0.617

High

179923

TLR3
Toll-like receptor 3

2

13

Small-scale

0.601

High

181780

SOCS1
Suppressor of cytokine signaling 1

2

8

Small-scale

0.601

High

352745

IFNA1
Interferon alpha-1/13

2

20

Small-scale

0.601

High

501016

TNF10
Tumor necrosis factor ligand superfamily member 10

2

7

Small-scale

0.601

High

501052

CASP8
Caspase-8

2

3

Small-scale

0.601

High

501059

XAF1
XIAP-associated factor 1

2

0

Small-scale

0.598

High

501074

CBP
CREB-binding protein

2

17

Small-scale

0.595

High

501076

KAT2B
Histone acetyltransferase KAT2B

2

8

Small-scale

0.595

High

389770

CY24B
Cytochrome b-245 heavy chain

3

3

Small-scale

0.585

High

500988

VCAM1
Vascular cell adhesion protein 1

3

1

Small-scale

0.585

High

397741

ISG15
Ubiquitin-like protein ISG15

2

10

Small-scale

0.584

High

456151

IFI6
Interferon alpha-inducible protein 6

2

1

Small-scale

0.584

High

486172

IL8
Interleukin-8

2

10

Small-scale

0.584

High

501007

PSB10
Proteasome subunit beta type-10

2

9

Small-scale

0.584

High

501051

STAT4
Signal transducer and activator of transcription 4

2

20

Small-scale

0.584

High

501063

IFNL1
Interferon lambda-1

2

7

Small-scale

0.584

High

501098

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

501056

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.582

High

501044

TRAF3
TNF receptor-associated factor 3

1

19

High-throughput

0.578

High

501026

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.561

High

501075

KAT2A
Histone acetyltransferase KAT2A

1

12

Small-scale

0.561

High

501097

DCAF1
DDB1- and CUL4-associated factor 1

1

1

Small-scale

0.561

High

417881

NPM
Nucleophosmin

1

0

Small-scale

0.554

High

501015

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.554

High

501027

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.554

High

501048

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.554

High

321869

RIGI
Antiviral innate immune response receptor RIG-I

1

7

Small-scale

0.534

High

500983

INGR1
Interferon gamma receptor 1

1

3

Small-scale

0.534

High

501013

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.518

High

396843

IL4
Interleukin-4

1

3

Small-scale

0.515

High

500980

CCL5
C-C motif chemokine 5

1

10

Small-scale

0.515

High

500985

CEBPB
CCAAT/enhancer-binding protein beta

1

3

Small-scale

0.515

High

500989

NUCL
Nucleolin

1

1

High-throughput

0.515

High

501019

HCFC1
Host cell factor 1

1

4

High-throughput

0.515

High

501025

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

501066

TRM2A
tRNA

1

1

High-throughput

0.515

High

501085

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.515

High

352911

IFNG
Interferon gamma

1

0

Small-scale

0.512

High

501000

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.501

High

501049

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

14

Small-scale

0.501

High

501014

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.481

High

500984

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.480

High

501034

SET
Protein SET

1

0

Small-scale

0.480

High

146143

ARI1A
AT-rich interactive domain-containing protein 1A

1

8

High-throughput

0.479

High

212240

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

265594

E2F6
Transcription factor E2F6

1

1

High-throughput

0.479

High

279416

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

344071

OAS1
2'-5'-oligoadenylate synthase 1

1

2

Small-scale

0.479

High

352458

TNFA
Tumor necrosis factor

1

7

Small-scale

0.479

High

352766

IFNA2
Interferon alpha-2

1

20

Small-scale

0.479

High

352837

IFN14
Interferon alpha-14

1

20

Small-scale

0.479

High

353039

IL2RA
Interleukin-2 receptor subunit alpha

1

1

Small-scale

0.479

High

377049

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

431467

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

485100

GLI3
Transcriptional activator GLI3

1

1

Small-scale

0.479

High

486731

MYB
Transcriptional activator Myb

1

2

Small-scale

0.479

High

487077

ANDR
Androgen receptor

1

4

Small-scale

0.479

High

500986

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

Small-scale

0.479

High

500990

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

1

Small-scale

0.479

High

500992

NCF2
Neutrophil cytosol factor 2

1

3

Small-scale

0.479

High

500995

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

500997

RBTN2
Rhombotin-2

1

1

Small-scale

0.479

High

500998

PSB8
Proteasome subunit beta type-8

1

9

Small-scale

0.479

High

501002

IL12B
Interleukin-12 subunit beta

1

8

Small-scale

0.479

High

501003

GBP1
Guanylate-binding protein 1

1

9

Small-scale

0.479

High

501006

MYH9
Myosin-9

1

2

Small-scale

0.479

High

501009

OX2G
OX-2 membrane glycoprotein

1

1

Small-scale

0.479

High

501011

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.479

High

501012

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.479

High

501017

SMCA2
Probable global transcription activator SNF2L2

1

4

High-throughput

0.479

High

501018

SMCA4
Transcription activator BRG1

1

4

Small-scale

0.479

High

501020

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.479

High

501021

IMA1
Importin subunit alpha-1

1

5

Small-scale

0.479

High

501022

STAT2
Signal transducer and activator of transcription 2

1

20

Small-scale

0.479

High

501023

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

501024

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.479

High

501029

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.479

High

501031

TF2B
Transcription initiation factor IIB

1

2

Small-scale

0.479

High

501036

SP2
Transcription factor Sp2

1

1

Small-scale

0.479

High

501038

DYST
Dystonin

1

1

Small-scale

0.479

High

501042

UBE3A
Ubiquitin-protein ligase E3A

1

6

Small-scale

0.479

High

501054

NFIX
Nuclear factor 1 X-type

1

4

Small-scale

0.479

High

501055

SSXT
Protein SSXT

1

5

High-throughput

0.479

High

501057

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

501058

ARID2
AT-rich interactive domain-containing protein 2

1

6

High-throughput

0.479

High

501060

ERAP2
Endoplasmic reticulum aminopeptidase 2

1

2

Small-scale

0.479

High

501061

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

3

High-throughput

0.479

High

501062

PB1
Protein polybromo-1

1

4

High-throughput

0.479

High

501065

ULK2
Serine/threonine-protein kinase ULK2

1

2

High-throughput

0.479

High

501067

IFNL3
Interferon lambda-3

1

7

Small-scale

0.479

High

501068

IL27A
Interleukin-27 subunit alpha

1

3

Small-scale

0.479

High

501069

ARI1B
AT-rich interactive domain-containing protein 1B

1

11

High-throughput

0.479

High

501070

PHF10
PHD finger protein 10

1

7

High-throughput

0.479

High

501071

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

High-throughput

0.479

High

501072

DPF1
Zinc finger protein neuro-d4

1

8

High-throughput

0.479

High

501073

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

501077

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

5

High-throughput

0.479

High

501081

ISG20
Interferon-stimulated gene 20 kDa protein

1

1

Small-scale

0.479

High

501082

TRI44
Tripartite motif-containing protein 44

1

10

Small-scale

0.479

High

501083

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

501084

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

501087

FOXP3
Forkhead box protein P3

1

6

Small-scale

0.479

High

501088

SP110
Sp110 nuclear body protein

1

6

Small-scale

0.479

High

501090

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

501093

EVL
Ena/VASP-like protein

1

1

Small-scale

0.479

High

501096

SATB2
DNA-binding protein SATB2

1

2

High-throughput

0.479

High

500979

IL7
Interleukin-7

1

2

Small-scale

0.470

High

501091

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

1

Small-scale

0.470

High

156998

AIM2
Interferon-inducible protein AIM2

1

0

Small-scale

0.458

High

399167

IL6
Interleukin-6

1

0

Small-scale

0.458

High

500982

MMP9
Matrix metalloproteinase-9

1

0

Small-scale

0.458

High

500993

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

500999

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

0

Small-scale

0.458

High

501005

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.458

High

501028

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

501030

H31
Histone H3.1

1

0

Small-scale

0.458

High

501035

NC2B
Protein Dr1

1

0

Small-scale

0.458

High

501053

NC2A
Dr1-associated corepressor

1

0

Small-scale

0.458

High

501064

MGAP
MAX gene-associated protein

1

0

High-throughput

0.458

High

501079

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

501080

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.458

High

501086

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

Small-scale

0.458

High

501094

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

Small-scale

0.458

High

130183

BT3A3
Butyrophilin subfamily 3 member A3

1

9

Small-scale

0.437

High

150307

CXL11
C-X-C motif chemokine 11

1

10

Small-scale

0.437

High

182251

TPSN
Tapasin

1

3

Small-scale

0.437

High

436003

CO1A2
Collagen alpha-2(I) chain

1

1

Small-scale

0.437

High

500996

CATS
Cathepsin S

1

3

Small-scale

0.437

High

501040

TAP2
Antigen peptide transporter 2

1

3

Small-scale

0.437

High

501089

IL21R
Interleukin-21 receptor

1

3

Small-scale

0.437

High

501092

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.269

Low

131869

UPK2
Uroplakin-2

1

0

Small-scale

0.249

Low

330219

I18BP
Interleukin-18-binding protein

1

0

Small-scale

0.249

Low

500994

MIME
Mimecan

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024