HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1030 Hs			1 758
+	Mm
		649211 ANS1B_MOUSE (44-836): 6.65e-73: 265: 15.88		MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63
+	Hs
		496939 ANK3_HUMAN (159-354): 1.67e-13: 77.6: 15.23		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497351 CSKI1_HUMAN (2-77): 1.09e-10: 68.4: 19.74		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		276136 PSD10_HUMAN (37-174): 3e-09: 60.5: 34.29		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		1056981 TNKS2_HUMAN (1-611): 2.38e-60: 227: 12.05		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		310053 TNKS1_HUMAN (1-682): 9.92e-60: 225: 12.67		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Rn
		251021 ANK3_RAT (159-354): 1.12e-15: 84.6: 15.74		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94107 ANK3_RAT (159-354): 1.12e-15: 84.6: 15.74		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		582027 CSKI1_RAT (2-77): 3.66e-10: 66.4: 19.74		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94253 CSKI1_RAT (2-77): 3.66e-10: 66.4: 19.74		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		883603 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		ZN469_HUMAN (7-623): 9.52e-09: 61.2: 10.94
+	Hs
		1295178 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		ZN469_HUMAN (7-623): 9.52e-09: 61.2: 10.94
+	Dm
		1361443 Q9VAU5_DROME (4-789): 1.18e-51: 201: 13.90		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96
+	Mm
		57360 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89
+	Mm
		57362 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63
+	Hs
		1336188 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		MAGE1_HUMAN (222-587): 4.83e-09: 61.9: 16.22
+	Dm
		1182373 Q7KU92_DROME (100-427): 2.38e-22: 106: 14.04		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96
+	Mm
		57444 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MYO15_MOUSE (50-503): 2.51e-11: 69.6: 13.00
+	Mm
		292551 INVS_MOUSE (152-919): 9.54e-16: 84.6: 8.55		MYO15_MOUSE (50-503): 2.51e-11: 69.6: 13.00