HitPredict

Interactor 1: RNF43 (Q68DV7)
E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
Gene: RNF43

Interactor 2: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32965059, 34702444
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005109 - frizzled binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 716
+	Hs
		159363 RNF43_HUMAN (1-783): 0: 710: 100.00		DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38
+	Hs
		159698 RNF43_HUMAN (1-783): 0: 710: 100.00		DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82
+	Hs
		1229005 RNF43_HUMAN (1-783): 0: 710: 100.00		PARD3_HUMAN (200-415): 1.57e-19: 96.2: 20.00
+	Hs
		1090145 RNF43_HUMAN (1-783): 0: 710: 100.00		PTN13_HUMAN (65-379): 1.39e-10: 67.2: 13.57
+	Hs
		159408 ZNRF3_HUMAN (42-668): 1.55e-79: 276: 29.38		DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38
+	Hs
		159916 ZNRF3_HUMAN (42-668): 1.55e-79: 276: 29.38		DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82
+	Hs
		1334574 RN149_HUMAN (36-348): 9.52e-78: 258: 18.21		GOPC_HUMAN (29-400): 2.6e-45: 170: 14.03
+	Mm
		651550 CBL_MOUSE (272-682): 4.24e-65: 235: 14.42		DLG1_MOUSE (17-656): 6.19e-50: 190: 14.10