HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 595
+	Hs
		370275 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		123297 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		370739 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369521 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370012 CDYL2_HUMAN (9-215): 3.69e-40: 154: 16.22		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369147 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369397 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		203613 SUV91_HUMAN (4-154): 1.01e-32: 131: 21.15		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370476 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		1269439 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269958 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1027160 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1237910 CDYL2_HUMAN (9-215): 3.69e-40: 154: 16.22		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269666 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		377842 CDY1_HUMAN (6-288): 6.05e-54: 193: 16.17		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		490090 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		COT1_HUMAN (105-555): 1.65e-109: 336: 23.62
+	Hs
		487919 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		RARA_HUMAN (81-545): 1.35e-102: 320: 22.37
+	Hs
		487212 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487765 SUV92_HUMAN (9-161): 9.77e-39: 148: 24.18		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487333 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16