HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15778465, 36736316
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 788
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (1-788): 0: 764: 96.57
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		684364 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (3-788): 0: 653: 59.90
+	Mm
		910318 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK1_MOUSE (3-788): 0: 642: 64.21
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (3-788): 0: 572: 48.33
+	Hs
		909567 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (34-733): 3.78e-144: 448: 31.08
+	Hs
		684349 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SNRK_HUMAN (48-787): 1.06e-145: 448: 23.85
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98
+	Hs
		684009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37
+	Hs
		684192 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		BRSK2_HUMAN (43-481): 4.15e-137: 424: 37.11
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Mm
		910272 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK2_MOUSE (34-481): 8.59e-138: 426: 36.60
+	Hs
		909507 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37
+	Hs
		909786 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		BRSK2_HUMAN (43-481): 4.15e-137: 424: 37.11
+	Hs
		684412 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK3_HUMAN (50-361): 5.13e-110: 366: 58.44