HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.985

Property	Details
Experiments	24457600, 27647897, 27705803, 9199346, 24981860, 33961781, 18453536, 19636380, 22325352, 26496610, 12829790, 37014752, 21282530, 22078878, 34316702, 17332741, 20601937
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 326
+	Hs
		123194 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Mm
		223225 CBX4_MOUSE (1-560): 5.82e-156: 459: 88.43		PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06
+	Hs
		718131 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Mm
		639466 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93
+	Hs
		717831 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		123257 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03
+	Dr
		1193374 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29
+	Hs
		123317 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12
+	Hs
		123312 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Dr
		1186372 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		BMI1B_DANRE (1-322): 4e-124: 360: 77.23
+	Hs
		123273 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44
+	Hs
		123174 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RO52_HUMAN (5-198): 5.75e-52: 180: 18.78
+	Hs
		123308 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		223231 CBX4_MOUSE (1-560): 5.82e-156: 459: 88.43		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Mm
		620782 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06
+	Hs
		123243 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Mm
		1164651 Q6TKP2_MOUSE (1-506): 1.06e-127: 390: 23.50		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Dr
		1193367 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		RING2_DANRE (7-227): 2.49e-47: 164: 16.27
+	Mm
		675501 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Mm
		193405 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		RING1_MOUSE (7-115): 1.2e-30: 121: 25.46