HitPredict

Interactor 1: VPS8 (Q8N3P4)
Vacuolar protein sorting-associated protein 8 homolog
Gene: VPS8

Interactor 2: TGFA1 (Q8WUH2)
Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
Gene: TGFBRAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33961781, 26463206, 35271311, 25266290
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0033263 - CORVET complex GO:0034058 - endosomal vesicle fusion GO:0035542 - regulation of SNARE complex assembly
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1428 Hs			1 860
+	Hs
		1232473 VPS8_HUMAN (1-1428): 0: 2003: 100.00		VPS18_HUMAN (248-845): 2.73e-108: 357: 12.19
+	Hs
		1232471 VPS8_HUMAN (1-1428): 0: 2003: 100.00		VPS11_HUMAN (23-854): 1.56e-92: 314: 12.50
+	Dm
		1097263 VPS8_DROME (44-1297): 0: 1271: 31.97		VPS18_DROME (248-859): 5.46e-101: 338: 13.64
+	Sc
		619697 VPS8_YEAST (77-1291): 0: 638: 18.19		VPS3_YEAST (28-800): 9.9e-79: 277: 14.25
+	Sc
		653809 VPS8_YEAST (77-1291): 0: 638: 18.19		PEP3_YEAST (252-853): 7.36e-75: 264: 12.93
+	Sc
		763455 VPS8_YEAST (77-1291): 0: 638: 18.19		VAM6_YEAST (431-850): 4.34e-66: 241: 19.78
+	Sc
		758407 VPS8_YEAST (77-1291): 0: 638: 18.19		VPS41_YEAST (296-817): 3.28e-51: 196: 12.68