Protein: PTN23
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)

Gene: PTN23, PTPN23
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q9H3S7

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924858

GRB2
Growth factor receptor-bound protein 2

5

20

Small-scale

0.936

High

275227

GRAP2
GRB2-related adapter protein 2

4

20

Small-scale

0.905

High

983667

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.771

High

338971

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

1260400

PDC6I
Programmed cell death 6-interacting protein

2

7

Small-scale

0.754

High

1330347

CHM4B
Charged multivesicular body protein 4b

4

11

Small-scale

0.706

High

277131

STAM2
Signal transducing adapter molecule 2

3

20

Small-scale

0.674

High

960968

CLH1
Clathrin heavy chain 1

3

2

Small-scale

0.671

High

1330352

UBAP1
Ubiquitin-associated protein 1

4

0

Small-scale

0.664

High

1189516

ZFY16
Zinc finger FYVE domain-containing protein 16

3

7

Small-scale

0.662

High

451731

CLCB
Clathrin light chain B

3

1

Small-scale

0.656

High

476367

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

7

Small-scale

0.651

High

160187

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

12

Small-scale

0.650

High

1306580

TS101
Tumor susceptibility gene 101 protein

2

4

Small-scale

0.631

High

132029

VMA5A
von Willebrand factor A domain-containing protein 5A

2

2

High-throughput

0.628

High

1189450

NT2NA
Notch homolog 2 N-terminal-like protein A

2

5

High-throughput

0.628

High

1291699

BICD1
Protein bicaudal D homolog 1

2

7

High-throughput

0.624

High

176497

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

Small-scale

0.618

High

385515

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

523149

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

685024

STIP1
Stress-induced-phosphoprotein 1

2

6

High-throughput

0.611

High

996514

FGL1
Fibrinogen-like protein 1

3

4

High-throughput

0.609

High

451554

CLCA
Clathrin light chain A

3

1

Small-scale

0.604

High

518766

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.586

High

875312

TERA
Transitional endoplasmic reticulum ATPase

2

9

High-throughput

0.584

High

1270618

STAM1
Signal transducing adapter molecule 1

2

20

Small-scale

0.584

High

1330355

ANFY1
Rabankyrin-5

2

4

Small-scale

0.584

High

1297198

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

1307434

SH3G2
Endophilin-A1

1

20

Small-scale

0.573

High

537064

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.573

High

638007

PSA3
Proteasome subunit alpha type-3

1

6

High-throughput

0.573

High

1120319

CEP55
Centrosomal protein of 55 kDa

1

2

High-throughput

0.573

High

1330350

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

Small-scale

0.552

High

309064

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.536

High

335189

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

381299

TBB4A
Tubulin beta-4A chain

1

5

High-throughput

0.536

High

607719

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.536

High

653375

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.536

High

653729

CALR
Calreticulin

1

10

High-throughput

0.536

High

714409

HSP74
Heat shock 70 kDa protein 4

1

7

High-throughput

0.536

High

776185

ARL1
ADP-ribosylation factor-like protein 1

1

8

High-throughput

0.536

High

871780

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

1057111

EPN4
Clathrin interactor 1

1

1

High-throughput

0.536

High

1104088

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1267749

HS105
Heat shock protein 105 kDa

1

7

High-throughput

0.536

High

1316203

DUS16
Dual specificity protein phosphatase 16

1

7

High-throughput

0.536

High

1329363

SLK
STE20-like serine/threonine-protein kinase

1

11

High-throughput

0.536

High

535932

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

713617

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1312780

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1330359

SNX12
Sorting nexin-12

1

0

High-throughput

0.513

High

259784

PDCD6
Programmed cell death protein 6

1

6

Small-scale

0.506

High

324030

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

390527

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.489

High

1224003

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1330353

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

1130584

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

Small-scale

0.481

High

64740

RHG32
Rho GTPase-activating protein 32

1

5

Small-scale

0.479

High

128912

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

Small-scale

0.479

High

205974

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

213003

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

228683

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

241197

TOM1
Target of Myb1 membrane trafficking protein

1

7

Small-scale

0.479

High

313568

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

8

Small-scale

0.479

High

321636

AP2A1
AP-2 complex subunit alpha-1

1

3

Small-scale

0.479

High

347881

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

530749

ITA4
Integrin alpha-4

1

12

High-throughput

0.479

High

553695

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

575847

VINC
Vinculin

1

1

High-throughput

0.479

High

592011

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.479

High

592493

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

614135

TBG1
Tubulin gamma-1 chain

1

10

High-throughput

0.479

High

652232

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

659049

MK01
Mitogen-activated protein kinase 1

1

12

High-throughput

0.479

High

672299

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.479

High

721429

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

777077

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

Small-scale

0.479

High

780094

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

787971

EPS15
Epidermal growth factor receptor substrate 15

1

16

Small-scale

0.479

High

826551

DHYS
Deoxyhypusine synthase

1

1

Small-scale

0.479

High

840577

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

845731

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.479

High

850192

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

854988

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

2

Small-scale

0.479

High

882564

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

909115

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

924163

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

Small-scale

0.479

High

961273

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

975026

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

1029866

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

1064145

TNIP1
TNFAIP3-interacting protein 1

1

8

Small-scale

0.479

High

1067470

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1070167

RABE1
Rab GTPase-binding effector protein 1

1

1

Small-scale

0.479

High

1078907

ITSN1
Intersectin-1

1

17

Small-scale

0.479

High

1080779

ZYX
Zyxin

1

10

High-throughput

0.479

High

1126375

SH319
SH3 domain-containing protein 19

1

20

Small-scale

0.479

High

1152097

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1167826

DNMBP
Dynamin-binding protein

1

17

Small-scale

0.479

High

1171692

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1173028

TM1L2
TOM1-like protein 2

1

7

Small-scale

0.479

High

1200660

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1254262

BICD2
Protein bicaudal D homolog 2

1

6

High-throughput

0.479

High

1301665

KS6C1
Ribosomal protein S6 kinase delta-1

1

7

Small-scale

0.479

High

1309495

TBA1C
Tubulin alpha-1C chain

1

4

Small-scale

0.479

High

1326738

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

1327568

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1330348

WNK1
Serine/threonine-protein kinase WNK1

1

10

Small-scale

0.479

High

1330349

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

1330351

BIRC6
Baculoviral IAP repeat-containing protein 6

1

5

Small-scale

0.479

High

1330356

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1330357

TBK1
Serine/threonine-protein kinase TBK1

1

14

Small-scale

0.479

High

1330361

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

Small-scale

0.479

High

514076

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.458

High

742531

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

1036473

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

Small-scale

0.458

High

1254715

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

Small-scale

0.458

High

1259792

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

1286536

ENTR1
Endosome-associated-trafficking regulator 1

1

0

Small-scale

0.458

High

1330358

RABX5
Rab5 GDP/GTP exchange factor

1

0

Small-scale

0.458

High

1330360

SYNRG
Synergin gamma

1

0

Small-scale

0.458

High

581861

VCAM1
Vascular cell adhesion protein 1

1

12

High-throughput

0.445

High

1269604

ESR2
Estrogen receptor beta

1

9

High-throughput

0.445

High

123718

PGRC1
Membrane-associated progesterone receptor component 1

1

5

Small-scale

0.437

High

165048

SC16A
Protein transport protein Sec16A

1

1

Small-scale

0.437

High

526059

IFM1
Interferon-induced transmembrane protein 1

1

4

High-throughput

0.437

High

823491

PAXI
Paxillin

1

9

High-throughput

0.437

High

926005

AP2B1
AP-2 complex subunit beta

1

2

Small-scale

0.437

High

965840

IFM3
Interferon-induced transmembrane protein 3

1

4

High-throughput

0.437

High

1254000

ALMS1
Centrosome-associated protein ALMS1

1

2

Small-scale

0.437

High

1315146

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

1330362

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

1326323

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.417

High

1235291

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1311032

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

1330354

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024