Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: RPB2 (P30876)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 35271311, 26496610, 29395067
Identification Methods affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains KOW~RNA_pol_Rpb2_6, KOW~RNA_pol_Rpb2_7, RNA_pol_Rpb2_1~Spt5-NGN
Common GO terms GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 1087
Hs

1 1174
+ Hs
+ Sc
+ Sc
+ Dm
+ Pf
+ Sc
+ Mm

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Last updated: 15 Jul 2024