HitPredict

Interactor 1: SMG8 (Q8ND04)
Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)
Gene: SMG8

Interactor 2: SMG1 (Q96Q15)
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)
Gene: SMG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.90 0.801

The method score is based on:

Property Details
Experiments 19417104, 20371770
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SMG1~Smg8_Smg9
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0005829 - cytosol
Homologous interactions 0

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Last updated: 15 Jul 2024