Protein: KLDC2
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)

Gene: KLDC2, KLHDC2
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q9Y2U9

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination
GO:0016604 - nuclear body
GO:0031462 - Cul2-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113031

CUL2
Cullin-2

6

20

Small-scale

0.732

High

1371903

CUL5
Cullin-5

5

20

Small-scale

0.716

High

1147312

ELOB
Elongin-B

4

4

Small-scale

0.694

High

1147153

ELOC
Elongin-C

3

3

Small-scale

0.667

High

1490943

ARI1
E3 ubiquitin-protein ligase ARIH1

3

14

High-throughput

0.667

High

967051

1433G
14-3-3 protein gamma

3

13

High-throughput

0.662

High

1295000

PTOV1
Prostate tumor-overexpressed gene 1 protein

3

1

High-throughput

0.662

High

1371218

GLMN
Glomulin

3

3

High-throughput

0.662

High

1308618

NUDC3
NudC domain-containing protein 3

4

20

High-throughput

0.630

High

1335897

RN169
E3 ubiquitin-protein ligase RNF169

2

1

High-throughput

0.628

High

1399512

IPO9
Importin-9

2

3

High-throughput

0.628

High

1450787

KTU
Protein kintoun

2

1

High-throughput

0.628

High

1454693

KLH42
Kelch-like protein 42

2

18

High-throughput

0.628

High

317227

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

2

4

Small-scale

0.608

High

956552

RAB2A
Ras-related protein Rab-2A

2

0

High-throughput

0.602

High

1280113

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.602

High

1387046

NMD3
60S ribosomal export protein NMD3

2

0

High-throughput

0.602

High

1404705

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.602

High

1460100

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

691564

1433T
14-3-3 protein theta

2

12

High-throughput

0.601

High

730382

1433B
14-3-3 protein beta/alpha

2

12

High-throughput

0.601

High

984029

RBX1
E3 ubiquitin-protein ligase RBX1

2

10

Small-scale

0.595

High

1143877

TCAL1
Transcription elongation factor A protein-like 1

2

0

High-throughput

0.576

High

1007348

TCPB
T-complex protein 1 subunit beta

2

18

High-throughput

0.574

High

1257059

SYDE1
Rho GTPase-activating protein SYDE1

2

8

High-throughput

0.574

High

1363720

TCPW
T-complex protein 1 subunit zeta-2

2

18

High-throughput

0.574

High

320803

UBXN7
UBX domain-containing protein 7

2

6

High-throughput

0.571

High

1155928

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.541

High

1154967

NEDD8
Ubiquitin-like protein NEDD8

1

5

Small-scale

0.536

High

990901

1433Z
14-3-3 protein zeta/delta

1

13

High-throughput

0.536

High

1120404

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

6

High-throughput

0.536

High

1383898

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1391978

DCNL1
DCN1-like protein 1

1

8

High-throughput

0.536

High

1405076

SORT
Sortilin

1

1

High-throughput

0.536

High

1431724

TARA
TRIO and F-actin-binding protein

1

18

High-throughput

0.536

High

1462282

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.536

High

1490942

KLDC2
Kelch domain-containing protein 2

1

17

Small-scale

0.516

High

730977

1433S
14-3-3 protein sigma

1

13

High-throughput

0.515

High

1462047

DD19B
ATP-dependent RNA helicase DDX19B

1

3

High-throughput

0.515

High

1215571

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1340908

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

0

High-throughput

0.513

High

1448658

STRN4
Striatin-4

1

5

High-throughput

0.494

High

702524

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

821629

TCPZ
T-complex protein 1 subunit zeta

1

16

High-throughput

0.489

High

876234

TCPE
T-complex protein 1 subunit epsilon

1

17

High-throughput

0.489

High

882226

TCPG
T-complex protein 1 subunit gamma

1

16

High-throughput

0.489

High

907700

CLCN2
Chloride channel protein 2

1

2

High-throughput

0.489

High

1049934

1433F
14-3-3 protein eta

1

12

High-throughput

0.489

High

1340122

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

1389527

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

10

High-throughput

0.489

High

1394312

TET5A
Terminal nucleotidyltransferase 5A

1

2

High-throughput

0.489

High

1410950

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

15

High-throughput

0.489

High

1458872

FBLN5
Fibulin-5

1

4

High-throughput

0.489

High

957563

UBC12
NEDD8-conjugating enzyme Ubc12

1

15

High-throughput

0.479

High

1364719

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

Small-scale

0.479

High

710921

EPHB2
Ephrin type-B receptor 2

1

1

Small-scale

0.445

High

958738

CSN2
COP9 signalosome complex subunit 2

1

20

High-throughput

0.445

High

1258627

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

7

High-throughput

0.445

High

1420909

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

9

High-throughput

0.445

High

1458373

RBX2
RING-box protein 2

1

13

High-throughput

0.445

High

1416324

COL11
Collectin-11

1

1

High-throughput

0.437

High

451466

NFM
Neurofilament medium polypeptide

1

9

High-throughput

0.407

High

1366082

PXDN
Peroxidasin homolog

1

2

High-throughput

0.407

High

1411612

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.407

High

1410664

SELS
Selenoprotein S

5

0

Small-scale

0.375

High

1017824

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

3

0

High-throughput

0.345

High

1437484

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

3

0

High-throughput

0.345

High

261896

PFD1
Prefoldin subunit 1

2

0

High-throughput

0.328

High

1315508

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

1406438

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.328

High

1450763

FAIM1
Fas apoptotic inhibitory molecule 1

2

0

High-throughput

0.328

High

1490946

SELK
Selenoprotein K

2

0

Small-scale

0.317

High

1242136

MTFR2
Mitochondrial fission regulator 2

2

0

High-throughput

0.313

High

1412855

CCM2
Cerebral cavernous malformations 2 protein

2

0

High-throughput

0.313

High

1429314

S22A4
Solute carrier family 22 member 4

2

0

High-throughput

0.313

High

335670

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

1258847

CYS1
Cystin-1

1

0

High-throughput

0.279

Low

1273213

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

1352588

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1451676

SDHF2
Succinate dehydrogenase assembly factor 2, mitochondrial

1

0

High-throughput

0.279

Low

281693

MTX2
Metaxin-2

1

0

High-throughput

0.232

Low

1490944

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.232

Low

1490945

INSL6
Insulin-like peptide INSL6

1

0

High-throughput

0.232

Low

1450712

RIC8B
Chaperone Ric-8B

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025