HitPredict

Interactor 1: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Interactor 2: DPY30 (Q9C005)
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
Gene: DPY30

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	26324722, 24981860
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 4911 Hs			1 99
+	Hs
		165713 SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Dm
		1129081 SET1_DROME (4698-4911): 6.13e-60: 232: 34.57		DPY30_DROME (42-99): 1.39e-24: 91.7: 51.72
+	Sp
		252202 SET1_SCHPO (4690-4911): 2.85e-63: 238: 37.82		SDC1_SCHPO (48-89): 9.88e-13: 60.5: 47.62
+	Hs
		975318 KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1018682 CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1318624 SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1318622 KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		152687 KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00