HitPredict

Interactor 1: THOC2 (Q8NI27)
THO complex subunit 2 (Tho2) (hTREX120)
Gene: THOC2

Interactor 2: THOC3 (Q96J01)
THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)
Gene: THOC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	26496610, 15998806, 17190602, 23222130, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Thoc2~WD40, ANAPC4_WD40~THOC2_N, THOC2_N~WD40
Common GO terms	GO:0000346 - transcription export complex GO:0000445 - THO complex part of transcription export complex GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0006406 - mRNA export from nucleus and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1593 Hs			1 351
+	Dm
		1367496 Q9VQ76_DROME (1216-1593): 8.73e-14: 79.1: 11.14		Q9VHT2_DROME (38-347): 1.57e-114: 336: 63.55
+	Hs
		1288263 SCAFB_HUMAN (1115-1590): 1.22e-31: 137: 11.16		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		1133288 RBM20_HUMAN (1030-1429): 5.51e-30: 131: 12.62		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		903218 EIF3A_HUMAN (1140-1576): 5.31e-14: 79.9: 7.47		WDR5_HUMAN (4-251): 1.76e-70: 224: 18.75
+	Hs
		903375 BD1L1_HUMAN (1140-1593): 4.25e-11: 70.7: 15.84		WDR5_HUMAN (4-251): 1.76e-70: 224: 18.75
+	Hs
		1191704 RBBP6_HUMAN (1129-1593): 1.23e-11: 72.2: 12.29		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		1132721 ZC3HD_HUMAN (1120-1593): 6.09e-11: 69.9: 8.37		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		1288258 MINT_HUMAN (1106-1593): 3.62e-09: 64.1: 9.78		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		1191731 RBBP6_HUMAN (1129-1593): 1.23e-11: 72.2: 12.29		NLE1_HUMAN (215-351): 2.9e-41: 152: 22.22
+	Hs
		1132750 ZC3HD_HUMAN (1120-1593): 6.09e-11: 69.9: 8.37		NLE1_HUMAN (215-351): 2.9e-41: 152: 22.22
+	Hs
		1281340 SCAFB_HUMAN (1115-1590): 1.22e-31: 137: 11.16		FBXW7_HUMAN (251-351): 8.37e-17: 83.5: 15.53
+	Hs
		1302927 MINT_HUMAN (1106-1593): 3.62e-09: 64.1: 9.78		NLE1_HUMAN (215-351): 2.9e-41: 152: 22.22
+	Hs
		1281379 NSRP1_HUMAN (1117-1593): 4.93e-24: 110: 9.33		FBXW7_HUMAN (251-351): 8.37e-17: 83.5: 15.53
+	At
		96053 THOC2_ARATH (1139-1589): 1.93e-10: 68.4: 10.61		THOC3_ARATH (260-351): 2.62e-19: 88.9: 21.43