HitPredict

Interactor 1: CHM4 (Q8T0Q4)
Charged multivesicular body protein 4 (CHMP4) (ESCRT-III complex core component shrb) (Protein Shrub)
Gene: shrb

Interactor 2: Q9VN02 (Q9VN02)
Charged multivesicular body protein 3 (Chromatin-modifying protein 3)
Gene: Vps24

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	14605208, 22036573
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0032509 - endosome transport via multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Dm			1 223
+	Ce
		1090380 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9U2F6_CAEEL (3-222): 8.3e-52: 169: 23.93
+	Dm
		1249820 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VRJ5_DROME (2-209): 1.68e-44: 149: 27.40
+	Dm
		1249815 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VBI3_DROME (3-202): 5.98e-43: 147: 24.00
+	Ce
		1090378 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9GYK4_CAEEL (1-211): 1.99e-44: 149: 49.76
+	At
		1013158 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	Hs
		1330574 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHMP3_HUMAN (1-223): 7.31e-52: 168: 57.40
+	Hs
		1349478 CHMP5_HUMAN (4-200): 1.53e-37: 132: 22.06		CHMP3_HUMAN (1-223): 7.31e-52: 168: 57.40
+	At
		1013164 VPS2A_ARATH (3-219): 2.44e-38: 134: 16.97		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	At
		98407 F4JXR3_ARATH (4-217): 1.56e-41: 144: 17.05		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	Dm
		1249812 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q95SH2_DROME (23-222): 2.92e-38: 133: 16.50
+	At
		1322582 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	Ce
		1090379 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9TXI3_CAEEL (22-223): 2.26e-38: 133: 12.38
+	At
		1322583 VPS2A_ARATH (3-219): 2.44e-38: 134: 16.97		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	Hs
		208860 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM2A_HUMAN (3-222): 2.42e-45: 152: 22.73
+	Hs
		1330562 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM2B_HUMAN (9-204): 2.59e-44: 149: 22.45
+	Hs
		208864 CHMP5_HUMAN (4-200): 1.53e-37: 132: 22.06		CHM2A_HUMAN (3-222): 2.42e-45: 152: 22.73
+	Hs
		1330513 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM1A_HUMAN (22-223): 2.63e-37: 130: 11.88
+	Hs
		1336683 CHMP5_HUMAN (4-200): 1.53e-37: 132: 22.06		CHM1A_HUMAN (22-223): 2.63e-37: 130: 11.88
+	Hs
		1185549 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM1B_HUMAN (23-223): 3.02e-35: 125: 13.93
+	Hs
		1185554 CHMP5_HUMAN (4-200): 1.53e-37: 132: 22.06		CHM1B_HUMAN (23-223): 3.02e-35: 125: 13.93