Protein: TBCD8
TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein)

Gene: TBCD8, TBC1D8
Organism: Homo sapiens
Interactions: 51
UniProt ID: O95759

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0008015 - blood circulation
GO:0008284 - positive regulation of cell population proliferation
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344390

RAB4A
Ras-related protein Rab-4A

2

19

High-throughput

0.675

High

344400

CDC42
Cell division control protein 42 homolog

1

15

High-throughput

0.618

High

340956

DIRA3
GTP-binding protein Di-Ras3

1

17

High-throughput

0.553

High

344399

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.553

High

344401

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.553

High

344402

RB11A
Ras-related protein Rab-11A

1

15

High-throughput

0.553

High

344409

RHOH
Rho-related GTP-binding protein RhoH

1

14

High-throughput

0.553

High

344414

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.553

High

344423

RHOV
Rho-related GTP-binding protein RhoV

1

17

High-throughput

0.553

High

344427

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.553

High

344386

TACD2
Tumor-associated calcium signal transducer 2

1

3

High-throughput

0.536

High

344391

GRAH
Granzyme H

1

3

High-throughput

0.536

High

344416

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

344421

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

2

High-throughput

0.536

High

344394

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.513

High

344420

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

344425

SORT
Sortilin

1

0

High-throughput

0.513

High

344405

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

High-throughput

0.489

High

344413

BTNL9
Butyrophilin-like protein 9

1

5

High-throughput

0.489

High

344419

THOC2
THO complex subunit 2

1

6

High-throughput

0.489

High

344426

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

344432

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

344385

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

344388

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

344393

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

344404

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

291168

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

299005

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

344396

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

344403

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.458

High

344422

DNJC1
DnaJ homolog subfamily C member 1

1

0

High-throughput

0.458

High

344429

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

344430

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

344407

SCRIB
Protein scribble homolog

1

4

High-throughput

0.457

High

344424

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

344389

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.437

High

344397

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.437

High

344398

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.437

High

344410

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.437

High

344411

OCLN
Occludin

1

1

High-throughput

0.437

High

344412

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

344417

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.437

High

344431

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.437

High

344392

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.407

High

344406

TRAF1
TNF receptor-associated factor 1

2

0

High-throughput

0.316

High

344395

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

344418

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.279

Low

344428

JPH1
Junctophilin-1

1

0

High-throughput

0.279

Low

344387

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

344408

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.249

Low

344415

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025