HitPredict

Interactor 1: A0A024R324 (A0A024R324)
Transforming protein RhoA
Gene: RHOA

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Roc
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005829 - cytosol GO:0007266 - Rho protein signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 2527
+	Hs
		900557 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		925337 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		894103 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		59884 A4D2P0_HUMAN (1-193): 5.16e-75: 226: 51.64		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		925792 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		892724 CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		925212 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	Hs
		893917 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20