HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 440
+	Hs
		808115 NEDD4_HUMAN (90-867): 0: 731: 35.94		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1036918 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1036914 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		808360 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		1056104 NED4L_HUMAN (5-867): 0: 785: 32.17		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78