HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: ASCC3 (Q8N3C0)
Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)
Gene: ASCC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 2202
+	Hs
		125048 WWP2_HUMAN (1-870): 0: 982: 100.00		U520_HUMAN (7-2198): 0: 1584: 37.61
+	Hs
		1232218 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		ASCC3_HUMAN (1-2202): 0: 1789: 100.00
+	Hs
		125617 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX17_HUMAN (407-898): 4.34e-100: 342: 12.97
+	Hs
		125142 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38
+	Hs
		125215 WWP2_HUMAN (1-870): 0: 982: 100.00		MTREX_HUMAN (366-1187): 1.53e-88: 316: 15.84
+	Hs
		124993 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Hs
		125480 WWP2_HUMAN (1-870): 0: 982: 100.00		SKI2_HUMAN (445-899): 1.93e-85: 310: 21.98
+	Hs
		133919 NEDD4_HUMAN (90-867): 0: 731: 35.94		DDX3X_HUMAN (1252-1734): 3.79e-90: 311: 12.50
+	Sc
		624167 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		DBP2_YEAST (338-896): 2.39e-99: 333: 13.50
+	Sc
		810906 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		MTR4_YEAST (1285-1848): 1.48e-90: 322: 21.35
+	Hs
		571603 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DDX5_HUMAN (1248-1735): 2.96e-100: 338: 11.38