HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SMRC1 (Q92922)
SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1)
Gene: SMARCC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1105
+	Mm
		956831 WWP2_MOUSE (1-870): 0: 971: 95.98		SMRC1_MOUSE (30-1074): 0: 1120: 95.70
+	Hs
		1272920 ITCH_HUMAN (1-870): 0: 902: 54.26		SMRC1_HUMAN (30-1074): 0: 1148: 100.00
+	Hs
		125594 WWP2_HUMAN (1-870): 0: 982: 100.00		SMRC2_HUMAN (32-1105): 0: 956: 57.71
+	Hs
		808208 NEDD4_HUMAN (90-867): 0: 731: 35.94		SMRC1_HUMAN (30-1074): 0: 1148: 100.00
+	Hs
		1251602 ITCH_HUMAN (1-870): 0: 902: 54.26		SMRC2_HUMAN (32-1105): 0: 956: 57.71
+	Hs
		125061 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24D_HUMAN (964-1100): 6.77e-10: 65.7: 25.00
+	Hs
		808106 NEDD4_HUMAN (90-867): 0: 731: 35.94		EP300_HUMAN (769-1082): 7e-28: 124: 13.19
+	Ce
		1341511 WWP1_CAEEL (6-366): 1.19e-31: 134: 19.44		Q9U3E2_CAEEL (825-1070): 6.19e-12: 71.9: 12.84
+	Ce
		106913 WWP1_CAEEL (6-366): 1.19e-31: 134: 19.44		LIDB1_CAEEL (825-1070): 1.68e-10: 66.9: 12.84