HitPredict

Interactor 1: UBP33 (Q8TEY7)
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)
Gene: USP33

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35191554
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 942 Hs			1 870
+	Hs
		1306555 UBP20_HUMAN (32-942): 0: 778: 58.27		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1085729 UBP20_HUMAN (32-942): 0: 778: 58.27		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		777070 UBP8_HUMAN (125-330): 4.91e-39: 159: 25.94		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1121190 UBP39_HUMAN (596-722): 8.74e-36: 145: 27.91		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1085724 UBP22_HUMAN (363-720): 8.74e-59: 212: 22.13		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1024405 UBP4_HUMAN (111-723): 6.57e-123: 398: 17.71		NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12
+	Hs
		777046 UBP8_HUMAN (125-330): 4.91e-39: 159: 25.94		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		292026 UBP2_MOUSE (115-434): 4.43e-47: 180: 19.95		BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91
+	Dm
		247722 Q9VDD8_DROME (181-330): 8.39e-38: 154: 31.95		CLOCK_DROME (16-651): 1.88e-96: 326: 16.62