Protein: SRGP2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)

Gene: SRGP2, SRGAP2
Organism: Homo sapiens
Interactions: 173
UniProt ID: O75044

Gene Ontology (top 5):
GO:0003363 - lamellipodium assembly involved in ameboidal cell migration
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212750

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

15

High-throughput

0.861

High

269487

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

2

17

Small-scale

0.811

High

269501

SRG2C
SLIT-ROBO Rho GTPase-activating protein 2C

2

18

Small-scale

0.754

High

269537

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.754

High

269575

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

2

18

High-throughput

0.737

High

269534

1433G
14-3-3 protein gamma

6

20

High-throughput

0.735

High

269520

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

269538

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.718

High

269542

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

269513

1433T
14-3-3 protein theta

5

20

High-throughput

0.703

High

269536

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.665

High

269581

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

5

High-throughput

0.628

High

245825

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.618

High

269497

RASK
GTPase KRas

1

19

High-throughput

0.618

High

269499

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

269504

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

269508

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

269515

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

269516

EPHB2
Ephrin type-B receptor 2

1

16

High-throughput

0.618

High

269532

ACTB
Actin, cytoplasmic 1

1

15

High-throughput

0.618

High

269533

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

269541

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

269547

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

High-throughput

0.618

High

269555

EPHA7
Ephrin type-A receptor 7

1

17

High-throughput

0.618

High

269560

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

9

High-throughput

0.618

High

269561

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.618

High

269566

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.618

High

269570

SYDE1
Rho GTPase-activating protein SYDE1

1

18

High-throughput

0.618

High

269572

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

269573

RFIP2
Rab11 family-interacting protein 2

1

10

High-throughput

0.618

High

269576

PHLB2
Pleckstrin homology-like domain family B member 2

1

14

High-throughput

0.618

High

269578

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.618

High

269579

KSR1
Kinase suppressor of Ras 1

1

18

High-throughput

0.618

High

269589

DEP1B
DEP domain-containing protein 1B

1

14

High-throughput

0.618

High

269601

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.618

High

269602

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.618

High

269612

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.618

High

269613

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

269623

ITSN2
Intersectin-2

1

7

Small-scale

0.618

High

269630

NGAP
Ras GTPase-activating protein nGAP

1

6

High-throughput

0.618

High

269635

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

8

High-throughput

0.618

High

269636

GAB2
GRB2-associated-binding protein 2

1

12

High-throughput

0.618

High

269638

STA13
StAR-related lipid transfer protein 13

1

16

High-throughput

0.618

High

269535

1433E
14-3-3 protein epsilon

2

10

High-throughput

0.611

High

269528

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

3

Small-scale

0.595

High

269529

YLPM1
YLP motif-containing protein 1

2

2

Small-scale

0.595

High

269617

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.590

High

269607

RTKN
Rhotekin

1

0

High-throughput

0.586

High

269624

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

162407

ANM5
Protein arginine N-methyltransferase 5

1

3

Small-scale

0.586

High

269495

HERC2
E3 ubiquitin-protein ligase HERC2

2

10

Small-scale

0.584

High

269554

PCM1
Pericentriolar material 1 protein

2

2

High-throughput

0.584

High

269492

FMNL1
Formin-like protein 1

1

6

Small-scale

0.578

High

269619

EXOC1
Exocyst complex component 1

2

1

High-throughput

0.576

High

269498

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

269565

AN34A
Ankyrin repeat domain-containing protein 34A

1

11

High-throughput

0.553

High

269586

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.553

High

269614

TANC2
Protein TANC2

1

7

High-throughput

0.553

High

269634

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.553

High

269605

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

269494

PCNT
Pericentrin

1

15

High-throughput

0.541

High

269641

ROBO1
Roundabout homolog 1

1

4

Small-scale

0.536

High

269505

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

269511

S100P
Protein S100-P

1

9

High-throughput

0.536

High

269539

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.536

High

269563

BSPRY
B box and SPRY domain-containing protein

1

5

High-throughput

0.536

High

269608

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

104929

APRIO
Alternative prion protein

2

8

High-throughput

0.533

High

269559

H2B2F
Histone H2B type 2-F

1

15

High-throughput

0.515

High

269595

ZN414
Zinc finger protein 414

1

0

High-throughput

0.513

High

269616

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

2

Small-scale

0.501

High

269598

ODAD1
Outer dynein arm-docking complex subunit 1

1

9

High-throughput

0.489

High

72696

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

4

Small-scale

0.479

High

176014

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.479

High

176789

DCLK1
Serine/threonine-protein kinase DCLK1

1

7

High-throughput

0.479

High

219536

WIPF1
WAS/WASL-interacting protein family member 1

1

4

Small-scale

0.479

High

230487

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.479

High

252394

DIAP1
Protein diaphanous homolog 1

1

5

Small-scale

0.479

High

269488

TULP3
Tubby-related protein 3

1

3

High-throughput

0.479

High

269489

GGYF1
GRB10-interacting GYF protein 1

1

6

High-throughput

0.479

High

269491

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.479

High

269496

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

269500

PROF1
Profilin-1

1

9

High-throughput

0.479

High

269506

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

269507

EZRI
Ezrin

1

10

High-throughput

0.479

High

269509

NF1
Neurofibromin

1

6

High-throughput

0.479

High

269512

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

269517

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

High-throughput

0.479

High

269518

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

269519

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

269521

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

269525

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

269527

MUC18
Cell surface glycoprotein MUC18

1

6

High-throughput

0.479

High

269530

AFAD
Afadin

1

20

High-throughput

0.479

High

269531

HDAC4
Histone deacetylase 4

1

10

High-throughput

0.479

High

269540

CDK16
Cyclin-dependent kinase 16

1

4

High-throughput

0.479

High

269543

CALD1
Caldesmon

1

16

High-throughput

0.479

High

269545

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.479

High

269546

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

10

High-throughput

0.479

High

269550

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

269552

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

269553

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

269556

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

17

High-throughput

0.479

High

269558

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.479

High

269562

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

269564

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.479

High

269567

LARP1
La-related protein 1

1

2

High-throughput

0.479

High

269568

GGYF2
GRB10-interacting GYF protein 2

1

15

High-throughput

0.479

High

269569

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

269574

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.479

High

269577

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

269580

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

269582

NAV1
Neuron navigator 1

1

2

High-throughput

0.479

High

269583

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

269585

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.479

High

269588

HDAC7
Histone deacetylase 7

1

10

High-throughput

0.479

High

269591

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

269592

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

269599

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

269604

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

269609

OSBL6
Oxysterol-binding protein-related protein 6

1

3

High-throughput

0.479

High

269611

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

269615

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.479

High

269618

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

3

High-throughput

0.479

High

269627

CING
Cingulin

1

3

High-throughput

0.479

High

269628

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

269629

LIMA1
LIM domain and actin-binding protein 1

1

7

High-throughput

0.479

High

269631

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

269632

ZBT21
Zinc finger and BTB domain-containing protein 21

1

11

High-throughput

0.479

High

269633

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

269639

KCTD3
BTB/POZ domain-containing protein KCTD3

1

12

High-throughput

0.479

High

163021

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

208605

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

245183

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

0

High-throughput

0.458

High

247555

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

251987

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

269493

NADK
NAD kinase

1

0

High-throughput

0.458

High

269523

TALDO
Transaldolase

1

0

High-throughput

0.458

High

269551

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.458

High

269587

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

269594

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

269597

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

269600

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

269603

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

269606

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

269621

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

269622

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

269625

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

269626

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

269637

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

269640

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

269526

HD
Huntingtin

1

7

High-throughput

0.457

High

269544

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

269596

SPTCS
Spatacsin

1

1

Small-scale

0.457

High

262185

SCN2B
Sodium channel regulatory subunit beta-2

1

3

High-throughput

0.445

High

269502

CALM3
Calmodulin-3

1

4

High-throughput

0.445

High

269503

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

269510

FPR1
fMet-Leu-Phe receptor

1

6

High-throughput

0.445

High

269522

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

269524

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.445

High

269548

PAK1
Serine/threonine-protein kinase PAK 1

1

4

Small-scale

0.445

High

269549

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

269571

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

7

High-throughput

0.445

High

269490

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

Small-scale

0.437

High

269514

CALX
Calnexin

1

2

High-throughput

0.437

High

269590

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.437

High

269593

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

269620

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

Small-scale

0.437

High

166225

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

269610

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

269557

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

269584

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025