Protein: SYDE1
Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)

Gene: SYDE1
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q6ZW31

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0007165 - signal transduction
GO:0016477 - cell migration
GO:0030036 - actin cytoskeleton organization
GO:0030695 - GTPase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127117

APBB1
Amyloid beta precursor protein binding family B member 1

4

3

High-throughput

0.691

High

971684

1433E
14-3-3 protein epsilon

2

12

High-throughput

0.628

High

269570

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

18

High-throughput

0.618

High

581130

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601342

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

953522

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955314

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

988469

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1257025

DEP1B
DEP domain-containing protein 1B

1

15

High-throughput

0.618

High

1257042

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1257044

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1257056

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

10

High-throughput

0.618

High

1257029

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

High-throughput

0.611

High

1257059

KLDC2
Kelch domain-containing protein 2

2

8

High-throughput

0.574

High

958135

ARP3
Actin-related protein 3

1

19

High-throughput

0.553

High

1216061

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.553

High

1257047

SH3B4
SH3 domain-binding protein 4

1

1

High-throughput

0.553

High

691158

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

729981

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

966509

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

1049463

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

228294

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

3

High-throughput

0.521

High

733952

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

5

High-throughput

0.521

High

889130

RBM25
RNA-binding protein 25

2

11

High-throughput

0.521

High

897875

CDK9
Cyclin-dependent kinase 9

2

7

High-throughput

0.521

High

915462

HMGA2
High mobility group protein HMGI-C

2

1

High-throughput

0.521

High

1036754

DSG1
Desmoglein-1

2

9

High-throughput

0.521

High

1213755

KPRP
Keratinocyte proline-rich protein

2

1

High-throughput

0.521

High

1257018

PHF6
PHD finger protein 6

2

5

High-throughput

0.521

High

1257030

P5CR2
Pyrroline-5-carboxylate reductase 2

2

5

High-throughput

0.521

High

1257039

MMTA2
Multiple myeloma tumor-associated protein 2

2

1

High-throughput

0.521

High

422401

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.489

High

1055328

APLP2
Amyloid beta precursor like protein 2

1

7

High-throughput

0.489

High

1199542

KLH22
Kelch-like protein 22

1

11

High-throughput

0.489

High

1257028

APBB2
Amyloid beta precursor protein binding family B member 2

1

3

High-throughput

0.489

High

1257032

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.489

High

1257058

RP3A
Rabphilin-3A

1

1

High-throughput

0.489

High

208693

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.479

High

637914

NF1
Neurofibromin

1

9

High-throughput

0.479

High

936366

AFAD
Afadin

1

20

High-throughput

0.479

High

1092451

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

High-throughput

0.479

High

1187117

TBC25
TBC1 domain family member 25

1

2

High-throughput

0.479

High

1216003

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

9

High-throughput

0.479

High

1257016

PHLB2
Pleckstrin homology-like domain family B member 2

1

18

High-throughput

0.479

High

1257034

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

1257035

TESK2
Dual specificity testis-specific protein kinase 2

1

4

High-throughput

0.479

High

1257038

RTKN
Rhotekin

1

2

High-throughput

0.479

High

1257045

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.479

High

1257050

LIMA1
LIM domain and actin-binding protein 1

1

10

High-throughput

0.479

High

1257052

NGAP
Ras GTPase-activating protein nGAP

1

9

High-throughput

0.479

High

1257055

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.479

High

1257057

GAB2
GRB2-associated-binding protein 2

1

15

High-throughput

0.479

High

508174

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.457

High

106154

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

172984

XPO1
Exportin-1

1

20

High-throughput

0.437

High

176844

DCLK1
Serine/threonine-protein kinase DCLK1

1

10

High-throughput

0.437

High

230542

KIF1C
Kinesin-like protein KIF1C

1

8

High-throughput

0.437

High

245242

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

6

High-throughput

0.437

High

252094

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.437

High

281354

GGYF1
GRB10-interacting GYF protein 1

1

9

High-throughput

0.437

High

339088

NADK
NAD kinase

1

1

High-throughput

0.437

High

671813

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.437

High

719236

MPIP2
M-phase inducer phosphatase 2

1

4

High-throughput

0.437

High

719343

MPIP3
M-phase inducer phosphatase 3

1

4

High-throughput

0.437

High

732343

PRDX2
Peroxiredoxin-2

1

7

High-throughput

0.437

High

910958

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.437

High

920059

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.437

High

941001

HDAC4
Histone deacetylase 4

1

10

High-throughput

0.437

High

962973

CH10
10 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.437

High

1025563

CDK16
Cyclin-dependent kinase 16

1

6

High-throughput

0.437

High

1065721

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

9

High-throughput

0.437

High

1129957

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.437

High

1133991

ZN638
Zinc finger protein 638

1

5

High-throughput

0.437

High

1152003

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

19

High-throughput

0.437

High

1159711

OCLN
Occludin

1

4

High-throughput

0.437

High

1217140

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.437

High

1219592

DEN4C
DENN domain-containing protein 4C

1

7

High-throughput

0.437

High

1226927

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.437

High

1229890

AN34A
Ankyrin repeat domain-containing protein 34A

1

13

High-throughput

0.437

High

1234838

PKHA7
Pleckstrin homology domain-containing family A member 7

1

19

High-throughput

0.437

High

1254346

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1257017

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.437

High

1257020

ARL14
ADP-ribosylation factor-like protein 14

1

13

High-throughput

0.437

High

1257021

NAV1
Neuron navigator 1

1

4

High-throughput

0.437

High

1257022

THOC2
THO complex subunit 2

1

5

High-throughput

0.437

High

1257023

F110B
Protein FAM110B

1

3

High-throughput

0.437

High

1257024

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.437

High

1257027

SRS12
Serine/arginine-rich splicing factor 12

1

7

High-throughput

0.437

High

1257031

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.437

High

1257033

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.437

High

1257036

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.437

High

1257037

F110A
Protein FAM110A

1

3

High-throughput

0.437

High

1257040

WDR33
pre-mRNA 3' end processing protein WDR33

1

6

High-throughput

0.437

High

1257041

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.437

High

1257043

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.437

High

1257046

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1257048

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.437

High

1257049

CING
Cingulin

1

5

High-throughput

0.437

High

1257053

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.437

High

1257054

ZBT21
Zinc finger and BTB domain-containing protein 21

1

13

High-throughput

0.437

High

1257060

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

1257061

KCTD3
BTB/POZ domain-containing protein KCTD3

1

14

High-throughput

0.437

High

516350

CALM1
Calmodulin-1

1

8

High-throughput

0.407

High

1257026

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

3

High-throughput

0.407

High

192830

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.328

High

667350

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.328

High

787755

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

0

High-throughput

0.328

High

912196

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.328

High

1234693

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.328

High

1257019

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.328

High

458016

TRY2
Trypsin-2

2

0

High-throughput

0.298

High

646869

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

1257051

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025