Protein: DEN1A
DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)

Gene: DEN1A, DENND1A
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q8TEH3

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0006897 - endocytosis
GO:0015031 - protein transport
GO:0030136 - clathrin-coated vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1219603

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.618

High

1277701

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.618

High

1352624

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.618

High

730083

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

971816

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.611

High

990533

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1352619

LIMA1
LIM domain and actin-binding protein 1

2

2

High-throughput

0.611

High

396577

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1234875

PKHA7
Pleckstrin homology domain-containing family A member 7

2

6

High-throughput

0.571

High

966659

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

1049597

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

171739

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.536

High

483372

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

1026147

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

1107580

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

1

High-throughput

0.536

High

1352600

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.536

High

948565

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1352615

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

612269

ARF4
ADP-ribosylation factor 4

1

7

Small-scale

0.501

High

1014930

ARF1
ADP-ribosylation factor 1

1

7

Small-scale

0.501

High

328707

VAMP5
Vesicle-associated membrane protein 5

1

3

High-throughput

0.489

High

173122

XPO1
Exportin-1

1

5

High-throughput

0.479

High

252124

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

269585

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.479

High

281380

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.479

High

339096

NADK
NAD kinase

1

1

High-throughput

0.479

High

401192

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

483165

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

637932

NF1
Neurofibromin

1

8

High-throughput

0.479

High

691273

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

719247

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

719355

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

730786

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

936395

AFAD
Afadin

1

13

High-throughput

0.479

High

941027

HDAC4
Histone deacetylase 4

1

9

High-throughput

0.479

High

989059

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

1025574

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.479

High

1065740

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.479

High

1092466

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.479

High

1134013

ZN638
Zinc finger protein 638

1

2

High-throughput

0.479

High

1216075

SPD2A
SH3 and PX domain-containing protein 2A

1

7

High-throughput

0.479

High

1245669

LARP1
La-related protein 1

1

1

High-throughput

0.479

High

1251389

GGYF2
GRB10-interacting GYF protein 2

1

8

High-throughput

0.479

High

1272873

RFIP2
Rab11 family-interacting protein 2

1

5

High-throughput

0.479

High

1276239

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1286521

PHLB2
Pleckstrin homology-like domain family B member 2

1

4

High-throughput

0.479

High

1293238

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

1309227

KSR1
Kinase suppressor of Ras 1

1

7

High-throughput

0.479

High

1322600

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

1349462

F110B
Protein FAM110B

1

3

High-throughput

0.479

High

1352596

HDAC7
Histone deacetylase 7

1

9

High-throughput

0.479

High

1352601

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.479

High

1352603

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1352604

F110A
Protein FAM110A

1

3

High-throughput

0.479

High

1352606

RTKN
Rhotekin

1

2

High-throughput

0.479

High

1352607

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.479

High

1352610

PKHA5
Pleckstrin homology domain-containing family A member 5

1

9

High-throughput

0.479

High

1352613

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

2

High-throughput

0.479

High

1352620

NGAP
Ras GTPase-activating protein nGAP

1

8

High-throughput

0.479

High

1352621

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1352622

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1352625

GAB2
GRB2-associated-binding protein 2

1

6

High-throughput

0.479

High

1352626

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1352627

STA13
StAR-related lipid transfer protein 13

1

6

High-throughput

0.479

High

1143441

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.460

High

163142

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

1352599

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1352616

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

1015072

ARF5
ADP-ribosylation factor 5

1

7

Small-scale

0.457

High

176853

DCLK1
Serine/threonine-protein kinase DCLK1

1

4

High-throughput

0.437

High

208707

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

4

High-throughput

0.437

High

230552

KIF1C
Kinesin-like protein KIF1C

1

6

High-throughput

0.437

High

245253

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.437

High

246068

KIF1B
Kinesin-like protein KIF1B

1

6

High-throughput

0.437

High

606933

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

1090161

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.437

High

1129965

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.437

High

1152018

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

8

High-throughput

0.437

High

1187125

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1216011

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

5

High-throughput

0.437

High

1229894

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.437

High

1257024

SYDE1
Rho GTPase-activating protein SYDE1

1

8

High-throughput

0.437

High

1338084

NAV1
Neuron navigator 1

1

4

High-throughput

0.437

High

1352595

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

12

High-throughput

0.437

High

1352597

DEP1B
DEP domain-containing protein 1B

1

3

High-throughput

0.437

High

1352598

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

1352602

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.437

High

1352605

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

1352611

TANC2
Protein TANC2

1

2

High-throughput

0.437

High

1352612

KI13B
Kinesin-like protein KIF13B

1

6

High-throughput

0.437

High

1352614

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1352617

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.437

High

1352618

CING
Cingulin

1

4

High-throughput

0.437

High

1352623

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.437

High

1352628

KCTD3
BTB/POZ domain-containing protein KCTD3

1

6

High-throughput

0.437

High

1340080

ATLA2
Atlastin-2

1

0

High-throughput

0.279

Low

1352609

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1024717

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1352608

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025