HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 779
+	Hs
		1294862 ITCH_HUMAN (1-870): 0: 902: 54.26		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1327913 WWP1_HUMAN (1-870): 0: 888: 58.38		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1299637 NED4L_HUMAN (5-867): 0: 785: 32.17		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1192214 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1231336 WWP1_HUMAN (1-870): 0: 888: 58.38		RHG24_HUMAN (55-181): 6.43e-27: 119: 25.93
+	Dm
		1278838 Q9W325_DROME (451-870): 1.26e-172: 508: 44.37		Q95R37_DROME (53-333): 2.92e-44: 163: 15.97
+	Hs
		1263850 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77
+	Hs
		1066132 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		ACAP2_HUMAN (28-517): 6.24e-39: 156: 13.10