HitPredict

Interactor 1: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Interactor 2: EXOS5 (Q9NQT4)
Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)
Gene: EXOSC5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	26496610, 33961781, 24981860, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, OB_Dis3~RNase_PH_C, RNB~RNase_PH
Common GO terms	GO:0000175 - 3'-5'-RNA exonuclease activity GO:0000177 - cytoplasmic exosome (RNase complex) GO:0005829 - cytosol GO:0006396 - RNA processing GO:0006401 - RNA catabolic process and 1 others more... GO:0016075 - rRNA catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 235
+	Hs
		1257153 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS4_HUMAN (9-235): 1.12e-75: 230: 26.47
+	Hs
		1257149 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS8_HUMAN (4-234): 4.65e-59: 189: 19.26
+	Hs
		1063744 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS7_HUMAN (1-233): 2.23e-46: 157: 15.52
+	Hs
		1130037 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS6_HUMAN (9-228): 2.79e-42: 146: 25.41
+	Hs
		1342631 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS4_HUMAN (9-235): 1.12e-75: 230: 26.47
+	Hs
		1343596 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS5_HUMAN (1-235): 2.29e-66: 206: 100.00
+	Hs
		1284999 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS8_HUMAN (4-234): 4.65e-59: 189: 19.26
+	Hs
		1063785 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS7_HUMAN (1-233): 2.23e-46: 157: 15.52
+	Dm
		1362696 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VK19_DROME (11-231): 3.08e-73: 224: 23.79
+	At
		96521 F4INI6_ARATH (1-972): 0: 934: 31.24		RRP41_ARATH (10-234): 2.62e-73: 224: 25.00
+	Sp
		194782 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP41_SCHPO (8-235): 3.68e-65: 204: 23.95
+	Dm
		1362694 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VGZ2_DROME (26-235): 9.54e-55: 177: 38.10
+	Sp
		194808 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP46_SCHPO (34-235): 1.7e-49: 163: 29.61
+	Dm
		1362699 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VW53_DROME (1-234): 2.23e-46: 158: 18.63
+	Sp
		252320 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP45_SCHPO (6-234): 4.64e-47: 158: 12.96
+	Sp
		740398 DIS3_SCHPO (5-972): 0: 941: 32.54		MTR3_SCHPO (23-235): 2.47e-42: 145: 18.58
+	Sc
		809596 RRP44_YEAST (2-971): 0: 893: 31.47		RRP41_YEAST (9-234): 9.01e-58: 185: 23.11
+	Dm
		1100453 Q9VC93_DROME (7-988): 0: 943: 31.52		Q29QQ9_DROME (1-228): 4.96e-31: 117: 17.46
+	Sc
		860819 RRP44_YEAST (2-971): 0: 893: 31.47		RRP46_YEAST (31-234): 4.86e-45: 151: 27.65
+	Sc
		816982 RRP44_YEAST (2-971): 0: 893: 31.47		MTR3_YEAST (29-180): 1.38e-13: 69.8: 17.05